Adams, JM and Cory, S (1998). The Bcl-2 protein family: arbiters of cell survival. Science. 281: 1322-1326.
Ali, NN; Harrison, MA; Rowe, JN and Teich, NM (1993). Spectrum of osteoblastic differentiation in new cell lines derived from spontaneous murine osteosarcomas. Bone. 14: 847-858.
Al-Khan, AA; Nimmo, JS; Tayebi, M; Ryan, SD; Simcock, JO; Tarzi, R; Kuntz, CA; Saad, ES; Day, MJ; Richardson, SJ and Danks, JA (2020). Parathyroid hormone receptor 1 (PTHR1) is a prognostic indicator in canine osteosarcoma. Sci. Rep., 10: 1-10.
Basso, FG; Silveira Turrioni, AP; Hebling, J and De Souza Costa, CA (2013). Zoledronic acid inhibits human osteoblast activities. Gerontology. 59: 534-541.
Boerman, I; Selvarajah, GT; Nielen, M and Kirpensteijn, J (2012). Prognostic factors in canine appendicular osteosarcoma-a meta-analysis. BMC Vet. Res., 8: 56.
Bruzzese, F; Pucci, B; Milone, MR; Ciardiello, C; Franco, R; Chianese, MI; Rocco, M; Di Gennaro, E; Leone, A; Luciano, A; Arra, C; Santini, D; Caraglia, M and Budillon, A (2013). Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways. Cell Death Dis., 4: e878.
Caraglia, M; Marra, M; Naviglio, S; Botti, G; Addeo, R and Abbruzzese, A (2010). Zoledronic acid: an unending tale for an antiresorptive agent. Expert. Opin. Pharmaco., 11: 141-154.
Cheung, LC; Tickner, J; Hughes, AM; Skut, P; Howlett, M; Foley, B; Oommen, J; Wells, JE; He, B; Singh, S; Chua, GA; Ford, J; Mullighan, CG; Kotecha, RS and Kees, UR (2018). New therapeutic opportunities from dissecting the pre-B leukemia bone marrow micro-environment. Leukemia. 32: 2326-2338.
Christou, A; Ferreira, N and Sophocleous, A (2023). Effects of zoledronic acid on osteosarcoma progression and metastasis: systematic review and meta-analysis. Clin. Exp. Med., 7: 3041-3051.
Conry, RM; Rodriguez, MG and Pressey, JG (2016). Zoledronic acid in metastatic osteosarcoma: encouraging progression free survival in four consecutive patients. Clin. Sarcoma Res., 6: 1-7.
Evdokiou, A; Labrinidis, A; Bouralexis, S; Hay, S and Findlay, DM (2003). Induction of cell death of human osteogenic sarcoma cells by zoledronic acid resembles anoikis. Bone. 33: 216-228.
Farley, JR; Kyeyune-Nyombi, E; Tarbaux, NM; Hall, SL and Strong, DD (1989). Alkaline phosphatase activity from human osteosarcoma cell line SaOS-2: an isoenzyme standard for quantifying skeletal alkaline phosphatase activity in serum. Clin. Chem., 35: 223-229.
Forest, V; Peoc’h, M; Campos, L; Guyotat, D and Vergnon, JM (2005). Effects of cryotherapy or chemotherapy on apoptosis in a non-small-cell lung cancer xenografted into SCID mice. Cryobiology. 50: 29-37.
Fu, D; He, X; Yang, S; Xu, W; Lin, T and Feng, X (2011). Zoledronic acid inhibits vasculogenic mimicry in murine osteosarcoma cell line in vitro. BMC Musculoskelet. Disord., 12: 146.
Ge, XY; Yang, LQ; Jiang, Y; Yang, WW; Fu, J and Li, SL (2014). Reactive oxygen species and autophagy associated apoptosis and limitation of clonogenic survival induced by zoledronic acid in salivary adenoid cystic carcinoma cell line SACC-83. PLoS One. 9: e101207.
Gregory, CA; Gunn, WG; Peister, A and Prockop, DJ (2004). An alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Ana. Biochem., 329: 77-84.
Heymann, D; Ory, B; Blanchard, F; Heymann, MF; Coipeau, P; Charrier, C; Couillaud, S; Thiery, JP; Gouin, F and Redini, F (2005). Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma. Bone. 37: 74-86.
Kavya, N; Rao, S; Sathyanarayana, ML; Narayanaswamy, HD; Byregowda, SM; Ranganath, L; Kamaran, A; Purushotham, KM and Kishore, TK (2017). Survivin expression in canine spontaneous cutaneous and subcutaneous tumors and its prognostic importance. Vet. World. 10: 1286-1291.
Koto, K; Murata, H; Kimura, S; Horie, N; Matsui, T; Nishigaki, Y; Ryu, K; Sakabe, T; Itoi, M; Ashihara, E; Maekawa, T; Fushiki, S and Kubo, T (2010). Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis, and shows combined effects with other anticancer agents. Oncol. Rep., 24: 233-239.
Liu, L; Geng, H; Mei, C and Chen, L (2021). Zoledronic acid enhanced the antitumor effect of cisplatin on orthotopic osteosarcoma by ROS-PI3K/AKT signaling and attenuated osteolysis. Oxid. Med. Cell. Longev., 2021: 6661534.
Livak, KJ and Schmittgen, TD (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods. 25: 402-408.
Nash, LA; Sullivan, PJ; Peters, SJ and Ward, WE (2015). Rooibos flavonoids, orientin and luteolin, stimulate mineralization in human osteoblasts through the Wnt pathway. Mol. Nutr. Food Res., 59: 443-453.
Orriss, IR; Key, ML; Colston, KW and Arnett, TR (2009). Inhibition of osteoblast function in vitro by amino-bisphosphonates. J. Cell Biochem., 106: 109-118.
Ory, B; Rogers, M and Heymann, D (2008). Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells. J. Cell Mol. Med., 12: 928-941.
Patntirapong, S; Singhatanadgit, W; Chanruangvanit, C; Lavanrattanakul, K and Satravaha, Y (2012). Zoledronic acid suppresses mineralization through direct cytotoxicity and osteoblast differentiation inhibition. J. Oral Pathol. Med., 41: 713-720.
Pautke, C; Schieker, M; Tischer, T; Kolk, A; Neth, P; Mutschler, W and Milz, S (2004). Characterization of osteosarcoma cell lines MG-63, Saos-2 and U-2 OS in comparison to human osteoblasts. Anticancer Res., 24: 3743-3748.
Poirier, VJ; Huelsmeyer, MK; Kurzman, ID; Thamm, DH and Vail, DM (2003). The bisphosphonates alendronate and zoledronate are inhibitors of canine and human osteosarcoma cell growth in vitro. Vet. Comp. Oncol., 1: 207-215.
Poradowski, D; Janus, I; Chrószcz, A and Obmińska-Mrukowicz, B (2021). In vitro studies on the influence of meloxicam on cytotoxic activity induced by risedronate sodium in canine (D-17) and human (U-2 OS) osteo-sarcoma cell lines. Animals. 11: 3135.
Ren, HY; Sun, LL; Li, HY and Ye, ZM (2015). Prognostic significance of serum alkaline phosphatase level in osteosarcoma: A meta-analysis of published data. Biomed.
Res. Int. 2015: 160835.
Rodriguez, LG; Wu, X and Guan, JL (2005). Wound-healing assay. Methods Mol. Biol., 294: 23-29.
Ryu, K; Murata, H; Koto, K; Horie, N; Matsui, T; Nishigaki, Y; Sakabe, T; Takeshita, H; Itoi, M; Kimura, S; Ashihara, E; Maekawa, T; Fushiki, S and Kubo, T (2010). Combined effects of bisphosphonate and radiation on osteosarcoma cells. Anticancer Res., 30: 2713-2720.
Shoeneman, JK; Ehrhart, EJ; Eickhoff, JC; Charles, JB; Powers, BE and Thamm, DH (2012). Expression and function of survivin in canine osteosarcoma. Cancer Res., 72: 249-259.
Smith, AA; Lindley, SE; Almond, GT; Bergman, NS; Matz, BM and Smith, AN (2023). Evaluation of zoledronate for the treatment of canine stage III osteosarcoma: A phase II study. Vet. Med. Sci., 9: 59-67.
Suva, LJ; Cooper, A; Watts, AE; Ebetino, FH; Price, J and Gaddy, D (2021). Bisphosphonates in veterinary medicine: The new horizon for use. Bone. 142: 115711.
Szewczyk, M; Lechowski, R and Zabielska, K (2015). What do we know about canine osteosarcoma treatment? Review. Vet. Res. Commun., 39: 61-67.
Tassone, P; Tagliaferri, P; Viscomi, C; Palmieri, C; Caraglia, M; D’Alessandro, A; Galea, E; Goel, A; Abbruzzese, A; Boland, CR and Venuta, S (2003). Zoledronic acid induces antiproliferative and apoptotic effects in human pancreatic cancer cells in vitro. Br. J. Cancer. 88: 1971-1978.
Tietz, NW; Burtis, CA; Duncan, P; Ervin, K; Petitclerc, CJ; Rinker, AD; Shuey, D and Zygowicz, ER (1983). A reference method for measurement of alkaline phosphatase activity in human serum. Clin. Chem., 29: 751-761.
Tobias, JH; Chow, JWM and Chambers, TJ (1993). 3-Amino-1-hydroxypropylidine-1-bisphosphonate (AHPrBP) suppresses not only the induction of new, but also the persistence of existing bone-forming surfaces in rat cancellous bone. Bone. 14: 619-623.
Uchide, T; Takatsu, N; Fujimori, Y; Fukushima, U and Itoh, H (2005). Expression of survivin mRNA in dog tumors. DNA Seq., 16: 329-334.
Ullén, A; Schwarz, S; Lennartsson, L; Kälkner, KM; Sandström, P; Costa, F; Lennerna, B; Linder, S and Nilsson, S (2009). Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines. Scand. J. Urol. Nephrol., 43: 98-103.
Wilson, H; Huelsmeyer, M; Chun, R; Young, KM; Friedrichs, K and Argyle, DJ (2008). Isolation and characterisation of cancer stem cells from canine osteosarcoma. Vet. J., 175: 69-75.
Yu, JQ; Bao, W and Lei, JC (2013). Emodin regulates apoptotic pathway in human liver cancer cells. Phyther. Res., 27: 251-257.
Zhang, R; Thamm, DH and Misra, V (2015). The effect of zhangfei/CREBZF on cell growth, differentiation, apoptosis, migration, and the unfolded protein response in several canine osteosarcoma cell lines. BMC Vet. Res., 11: 1-11.