Clinicopathological investigation of nutritional osteodystrophia fibrosa in a flock of young stall-fed goats

Document Type : Scientific report

Authors

1 Ph.D. Student in Veterinary Pathology, Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India

2 Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India

3 1Ph.D. Student in Veterinary Pathology, Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India

4 Ph.D. Student in Animal Nutrition, Division of Animal Nutrition, ICAR-National Dairy Research Institute, Karnal, 132001, Haryana, India

5 Ph.D. Student in Animal Nutrition, Division of Animal Nutrition, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India

Abstract

Background: Osteodystrophia fibrosa (ODF) is a metabolic disorder affecting the skeletal system, causing progressive loss of calcified bone mass and its replacement with fibrous tissue, which may be a sequel to primary or secondary hyperparathyroidism. This report intends to document the clinicopathological findings of ODF in a flock of young goats fed primarily on a wheat bran-rich diet. Case description: In a flock of 50 stall-fed goats aged 1 to 2 years, seven were clinically presented with bilateral facial enlargement, leading to dyspnea and difficulty in prehension and mastication. Among the seven clinically affected goats, four died in 2 months. Findings/treatment and outcome: The clinical examination revealed bilateral mandibular enlargement and limb deformities. On radiography, the maxilla and mandible had decreased radiopacity. Fine needle aspiration cytology (FNAC) from the affected bones showed occasional fibroblasts and individual osteoclasts clusters. On necropsy, the enlarged mandible revealed a meaty consistency. Undecalcified histological sections of the mandible showed severe osteopenia, multiple osteoclasts, Howship’s lacunae, and extensive fibroplasia. Dietary corrective measures led to the prevention of ODF in the rest of the flock. Conclusion: Excessive wheat bran feeding in stallfed goats might have led to calcium and phosphorus imbalance, resulting in nutritional secondary hyperparathyroidism and subsequent skeletal deformities. FNAC of the affected bones, gross and histological findings provide a clinicopathological diagnosis of ODF.

Keywords

Main Subjects

References

Akter, S; Kamal, MAHM; Islam, MN; Hoque, MA and Rahman, MM (2018). Clinical case report on nutritional dystrophy in goats at SA Quadary Veterinary Teaching Hospital, CVASU, Chittagong. Bangladesh J. Vet. Med., 16: 175-181.
Aslani, MR; Movassaghi, AR; Mohri, M and Seifi, HA (2001). Outbreak of osteodystrophia fibrosa in young goats. J. Vet. Med., 48: 385-389.
Bas, S; Bas, A; Lopez, I; Estepa, JC; Rodriguez, M and Aguilera-Tejero, E (2005). Nutritional secondary hyperparathyroidism in rabbits. Domest. Anim. Endocrinol., 28: 380-390.
Bharti, D; Ajith, Y; Madhesh, E; Verma, NK; Singh, M; Kalaiselvan, E and Dimri, U (2021). Nutritional secondary hyperparathyroidism–induced facial osteodystrophy in a Labrador puppy. J. Comp. Pathol., 30: 101-106.
Doige, CE and Weisbroge, SE (1995). Diseases of bone and joints. In: Carlton, WW and McGavin, MD (Eds.), Thomson’s special veterinary pathology. (2nd Edn.), Mosby, St. Louis. P: 446.
Heuze, V; Tran, G; Baumont, R; Noblet, J; Renaudeau, D; Lessire, M and Lebas, F (2015). Wheat bran. Feedipedia, FAO. https://www.feedipedia.org/node/726.
Lynch, MJ; Slocombe, RF; Harrigan, KE and Laing, CJ (1999). Fibrous osteodystrophy in dromedary camels (Camelus dromedarius). J. Zoo Wildl. Med., 1: 577-583.
Ozmen, O; Şahinduran, S; Aydogan, A; Sevgisunar, NS and Haligur, M (2017). Clinical and pathological studies on nutritional fibrous osteodystrophy in goats. Ankara Univ. Vet. Fak. Derg., 64: 55-59.
Pavarini, SP; Santos, ASD; Bandarra, PM; Antoniassi, NAB; Cruz, CEFD and Driemeier, D (2011). Nutritional fibrous osteodystrophy in goats. Pesq. Vet. Bras., 10: 875-878.
Radostits, OM; Gay, CC; Hinchcliff, KW and Constable, PD (2007). Veterinary medicine: A textbook of the diseases of cattle, horses, sheep, pigs, and goats. 10th Edn., London,
Saunders. PP: 633-634.
Sharma, M; Karikalan, M; Dandapat, P; Kumar, MA; Beena, V; Mohan, SC and Sharma, AK (2022). Tuberculosis in free-ranging and captive wild animals: Pathological and molecular diagnosis with histomorphological differentiation of granulomatous lesions. Microb. Pathog., 172: 105752.
Smith, MC and Sherman, DM (2011). Goat medicine. 2nd Edn., New Jersey, USA, John Wiley and Sons. P: 88.
Stewart, J; Liyou, O and Wilson, G (2010) Bighead in horses–not an ancient disease. Aust. Equine Vet., 29: 55-62.
Strzalka, W and Ziemienowicz, A (2011). Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation. Ann. Bot., 107: 1127-1140.
Thompson, K (2007). Bones and joint. In: Maxie, MG (Ed.), Jubb, Kennedy, and Palmer’s pathology of domestic animals. (5th Edn.), Philadelphia, Elsevier. PP: 82-88.
Varshney, JP; Gulshan Kumar, and Shanker, KS (2018). Evaluation of promising biochemical markers of nutritional osteodystrophy in goats. Small Rumin. Res., 169: 86-89.

Files

Share

How to cite

Statistics