ارزیابی اثر لیدوکائین، فنتانیل یا دکسمدتومیدین بر حداقل سرعت انفوزیون وریدی و متغیرهای قلبی تنفسی در سگ‌های تحت بیهوشی تام وریدی با کتوفول

نوع مقاله : مقاله کامل

نویسندگان

چکیده

پیشینه: پیشنهاد شده است که کاهش دوز با استفاده از تزریق همزمان داروهای دیگر، ممکن است دپرس تنفسی ناشی از کتوفول را بهبود بخشد. هدف: مطالعه حاضر با هدف ارزیابی اثرات افزودن لیدوکائین، فنتانیل یا دکیمدتومیدین بر دوز مورد نیاز و متغیرهای قلبی تنفسی در سگ‌های تحت بیهوشی تام وریدی (TIVA) با کتوفول طراحی شد. روش کار: در فاز I، دوازده سگ (شش قلاده در هر گروه درمانی) با دو تا از چهار رژیم‌ بیهوشی 1- کتوفول (4 میلی‌گرم بر کیلوگرم و 3/0 میلی‌گرم بر کیلوگرم؛ KET)، 2- کتوفول و لیدوکائین (5/1 میلی‌گرم بر کیلوگرم و 25/0 میلی‌گرم بر کیلوگرم در دقیقه؛ KLD)، 3- کتوفول و فنتانیل (5 میکروگرم بر کیلوگرم و 1/0 میکروگرم بر کیلوگرم در دقیقه؛ KFN)، و 4- کتوفول و دکسمدتومیدین (2 میکروگرم بر کیلوگرم و 2 میلی‌گرم بر کیلوگرم در ساعت؛ KDX) با فاصله حداقل یک هفته‌ای القا و نگهداری شدند. حداقل سرعت وریدی (MIR) کتوفول تعیین شد. در فاز II، 12 سگ دیگر رژیم مشابهی را برای 60 دقیقه با سرعت وریدی تعیین شده کتوفول دریافت نموده و متغیرهای قلبی تنفسی در آن‌ها اندازه‌گیری ثبت شد. نتایج: متوسط MIR کتوفول برای KET، KLD، KFN، و KDX به ترتیب 35/0، 23/0، 15/0، و 08/0 میلی‌گرم بر کیلوگرم در دقیقه تعیین شد. در فاز II، زمان‌های ریکاوری در گروه KFN و KDX کوتاهتر از KET و KLD بود. ضربان قلب به صورت معنی‌داری در زمان بیهوشی در گروه‌های KET و KLD بیشتر و در گروه‌های KFN و KDX پایین‌تر از زمان پایه در چند نقطه زمانی تعیین شد. در همه درمان‌ها، دپرس تنفسی مشاهده گردید. نتیجه‌گیری: علی‌رغم کاهش دوز کتوفول، هیچ یک از داروهای مورد استفاده نتوانست دپرس تنفسی ناشی از کتوفول را کاهش دهد.

کلیدواژه‌ها


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