Successful treatment of cardiac dysrhythmia associated with foot and mouth disease in a calf

Document Type : Scientific report


1 Animal Experimentation Station, Indian Veterinary Research Institute, Regional Campus, Hebbal, Bengaluru-560024, India

2 Division of Medicine, Indian Veterinary Research Institute, Bareilly-243122, Uttar Pradesh, India

3 FMD Research Laboratory, Indian Veterinary Research Institute, Regional Campus, Hebbal, Bengaluru-560024, India


Background: Foot and mouth disease (FMD), which causes myocarditis, results in 50% sudden death in the suckling calves. Occurrence of arrhythmias associated with FMD induced myocarditis in calves is not reported hitherto. ‏‏‏The present work documents the arrhythmias associated with FMD in calf and their treatment using appropriate antiarrhythmic drugs. Case description: A three-month-old male Holstein Friesian crossbred calf naturally suffering from FMD was selected for the present study. Findings/treatment and outcome: Cardiac auscultation revealed grade 4 systolic murmurs and electrocardiography (ECG) showed sustained polymorphic ventricular premature complexes (PVPCs) with tachycardia on bipolar base apex lead. Apart from standard treatment, lidocaine 2% was administered at dose of 0.6 mg/kg intravenously over 15 min once a day and sinus rhythm was restored by 76 h post-treatment. Review of ECG and haematobiochemical examination revealed normal findings on 7th day of treatment. Conclusion: The study demonstrates the presence of sustained PVPCs with tachycardia due to FMD induced myocarditis and the successful use of lidocaine in restoring the sinus rhythm and recovery of the calf.


Aktas, MS; Ozkanlar, Y; Oruc, E; Sozdutmaz, I and Kirbas, A (2015). Myocarditis associated with foot-and-mouth disease in suckling calves. Vet. Arhiv., 85: 273-282.
Alexandersen, S; Zhang, Z; Donaldson, AI and Garland, AJM (2003). The pathogenesis and diagnosis of foot-and-mouth disease. J. Comp. Pathol., 129: 1-36.
Aslani, MR; Mohri, M and Movassaghi, AR (2013). Serum troponin I as an indicator of myocarditis in lambs affected with foot and mouth disease. Vet. Res. Forum. 4: 59-62.
Barker, IK; Van Dreumel, AA and Palmer, N (1993). The alimentary system. In: Jubb, KVF; Kennedy, PC and Palmer, N (Eds.), Pathology of domestic animals. (4th Edn.), San Diego, CA, Academic Press. PP: 141-144.
Baski, AJ; Kanaganayagam, GS and Prasad, SK (2015). Arrhythmias in viral myocarditis and pericarditis. Card. Electrophysiol. Clin., 7: 269-281.
Brown, CC; Meyer, RF; Olander, HJ; House, C and Mebus, CA (1992). A pathogenesis study of foot-and-mouth disease in cattle, using in-situ hybridization. Can. J. Vet. Res., 56: 189-193.
Deluigi, CC; Ong, P; Hill, S; Wagner, A; Kispert, E; Klingel, K; Kandolf, R; Sechtem, U and Mahrholdt, H
(2013). ECG findings in comparison to cardiovascular MR imaging in viral myocarditis. Int. J. Cardiol., 165: 100-106.
El Beskawy, MA; Farag, VM and Saad, MA (2016). Epidemiological and clinicopathological studies of sheep naturally infected with foot and mouth disease virus (SAT2) in Egypt. Alex. J. Vet. Sci., 49: 129-137.
Kaya, A; Kozat, S; Ozkan, C; Yildirim, S; Akgul, Y and Akgul, O (2013). Serum homocysteine levels in calves with foot and mouth disease. J. Anim. Vet. Adv., 12: 1357-1361.
Klein, RM; Vester, EG; Brehm, MU; Dees, H; Picard, F; Niederacher, D; Beckmann, MW and Strauer, BE (2000). Inflammation of the myocardium as an arrhythmia trigger. Z. Kardiol., 3: 24-35.
Radostits, OM; Gay, CC; Hinchcliff, KW and Constable, PD (2007). Veterinary medicine. A textbook of the diseases of cattle, horses, sheep, pigs and goats. 10th Edn., London, UK, W. B. Saunders. PP: 1223-1230.
Sheu, SS and Lederer, WJ (1985). Lidocaine’s negative inotropic and antiarrhythmic actions. Dependence on shortening of action potential duration and reduction of intracellular sodium activity. Circ. Res., 57: 578-590.
Sobhy, NM; Yasmin, HB; Sunil, KM; El-Zahara, HI and Goyal, SM (2018). Outbreaks of foot and mouth disease in Egypt: molecular epidemiology, evolution and cardiac biomarkers prognostic significance. Int. J. Vet. Sci. Med., 6: 22-30.
Ukena, C; Mahfoud, F; Kindermann, I; Kandolf, R; Kindermann, M and Bohm, M (2011). Prognostic electrocardiographic parameters in patients with suspected myocarditis. Eur. J. Hrt. Fail., 13: 398-405.