مقاومت رنوواسکولار غیر طبیعی در سگ‌های مبتلا به دیابت شیرین: همبستگی بین شرایط گلایسمیک و پروتئینوری

نوع مقاله : مقاله کامل

نویسندگان

چکیده

مطالعه حاضر با هدف تعیین مقاومت عروقی کلیه در سگ‌های مبتلا به دیابت و بررسی همبستگی بین شاخص‌های مقاومت رنوواسکولار با وضعیت گلایسمیک، فشار خون سیستولیک (SBP) و پروتئینوری در سگ‌های دیابتیک انجام شد. این مطالعه بر روی 17 قلاده سگ دیابتی و 10 قلاده سگ به ظاهر سالم انجام شد. شاخص مقاومتی (RI) و شاخص ضربانی (PI) کلیه در سگ‌های دیابتی در مقایسه با سگ‌های سالم افزایش یافته بود. افزایش فشار خون سیستمیک و پروتئینوری به ترتیب در 10 و 3 مورد از 17 سگ دیابتی مشاهده شد. همبستگی مثبت و معنی‌داری بین شاخص‌های مقاومت رنوواسکولار و سطح گلوکز خون ناشتا و همچنین بین شاخص‌های مقاومت رنوواسکولار و سطح هموگلوبین گلیکوزیله سرم مشاهده شد. هیچ گونه همبستگی بین شاخص‌های مقاومت رنوواسکولار و SBP و همچنین بین شاخص‌های مقاومت رنوواسکولار و پروتئینوری مشاهده نشد. از آن جایی که شاخص‌های رنوواسکولار همبستگی معنی‌داری با وضعیت گلایسمیک دارند، می‌توان از آن‌ها به عنوان مارکر‌های اولیه برای آسیب‌های کلیوی در بیماران دیابتی استفاده کرد. در میان این شاخص‌ها PI کلیوی بسیار حساس‌تر از RI کلیوی بود.

کلیدواژه‌ها


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