مقایسه لیدوکائین، لیدوکائین-دگزامتازون و لیدوکائین-اپی‌نفرین در بی‌حسی اپیدورال خلفی در گاو

نوع مقاله : مقاله کامل

نویسندگان

چکیده

هدف از مطالعه حاضر تعیین اثر اضافه نمودن دگزامتازون یا اپی‌نفرین به لیدوکائین بر شاخص‌های بی‌حسی و متغیرهای قلبی تنفسی به دنبال بی‌حسی اپیدورال خلفی در گاو بود. بیست رأس گاو شیری به صورت تصادفی تقسیم شدند تا یکی از درمان‌های لیدوکائین (LID، 2/0 میلی‌گرم بر کیلوگرم)، دگزامتازون (DEX، 8 میلی‌گرم)، لیدوکائین-دگزامتازون (LIDEX، به ترتیب 2/0 میلی‌گرم بر کیلوگرم و 8 میلی‌گرم) و لیدوکائین-اپی‌نفرین (LIDEP، به ترتیب 2/0 میلی‌گرم بر کیلوگرم و 5 میکروگرم بر میلی‌لیتر) را به صورت اپیدورال دریافت کنند. حجم نهایی تمام تزریقات برابر با 018/0 میلی‌لیتر بر کیلوگرم تنظیم و 10 میلی‌لیتر به عنوان حجم نهایی در نظر گرفته شد. زمان شروع و طول دوره بی‌حسی و ضربان قلب، تعداد تنفس و دمای مقعدی ثبت گردیدند. هیچ اثر بی‌حسی موضعی در گروه DEX مشاهده نشد. زمان شروع بی‌حسی بین سه گروه LID، LIDEX و LIDEP تفاوت معنی‌داری را نشان نداد. طول دوره بی‌حسی به صورت معنی‌داری در گروه LIDEX (8/25 ± 4/152 دقیقه) در مقایسه با LID (5/11 ± 0/116 دقیقه) معنی‌دار بود. با این که طول دوره بی‌حسی در گروه LIDEP (0/10 ± 7/137 دقیقه) در مقایسه با گروه LID طولانی‌تر بود، ولی این تفاوت معنی‌دار نبود. تفاوت معنی‌داری در زمان شروع و طول دوره بی‌حسی بین گروه LIDEX و LIDEP نبود. ضربان قلب، تعداد تنفس و دمای مقعدی تفاوت معنی‌داری را در طول زمان نشان ندادند. عدم تعادل ملایم و گذرا در سه گروه دریافت کننده محلول بی‌حسی حاوی لیدوکائین مشاهده شد. نتیجه‌گیری شد که اضافه نمودن دگزامتازون به لیدوکائین بدون تغییر در زمان شروع، بی‌حسی طولانی‌تری را نسبت به لیدوکائین تنها در بی‌حسی اپیدورال خلفی در گاو ایجاد می‌نماید.

کلیدواژه‌ها


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