Bancroft, JD and Marilyn, G (2008). Theory and practice of histological techniques. 1st Edn., London, Elsevier Limited. PP: 168-173.
Blachier, F; Mariotti, F; Huneau, JF and Tome, D (2007). Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences. Amino Acids. 33: 547-562.
Brioche, T; Pagano, AF; Py, G and Chopard, A (2016). Muscle wasting and aging: experimental models, fatty infiltrations, and prevention. Mol. Aspects Med., 50: 56-87.
Britton, KE; Quinn, EV; Brown, BL and Eknis, PP (1957). A strategy for thyroid function tests. Br. Med. J., 3: 350-360.
Buyse, J; Swennen, Q; Vandemaele, F; Klasing, KC; Niewold, TA; Baumgartner, M and Goddeeris, BM (2009). Dietary β-hydroxy-β-methyl butyrate supplemen-tation influences performance differently after immunization in broiler chickens. J. Anim. Physiol. Anim. Nutr., 93: 512-524.
Davey, MW; Stals, E; Panis, B; Keulemans, J and Swennen, RL (2005). High-throughput determination of malondial-dihyde in plant tissues. Ana. Biochem., 347: 201-207.
Egan, H; Kirk, RS and Sawyer, R (1981). Pearsons chemical analysis of foods. 8th Edn., Edinburgh, UK, Churchill Livingstone. PP: 325-329.
Eley, HL; Russell, ST; Baxter, JH; Mukerji, P and Tisdale, MJ (2007). Signaling pathways initiated by beta-hydroxy-beta-methyl butyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am. J. Physiol. Endocrinol. Metab., 293: 923-931.
EL-Kafoury, MA; Kalleny, NK and Hamam, GG (2011). Effect of amino acid L-leucine on the musculo-skeletal changes during cast-immobilization I adult male Albino rats. Physiological and histological study. Life Sci., 8: 876-892.
Ferguson, LD and Walters, MR (2011). Xanthine oxidase inhibition for the treatment of stroke disease: a novel therapeutic approach. Exp. Rev. Cardiovasc. Ther., 9: 399-401.
Foya, OT and Ferket, PR (2006). Effect of in vivo feeding egg with protein, beta-hydroxy-beta-methyl butyrate and carbohydrate on glycogen status and neonatal growth of turkeys. Poul. Sci., 85: 1185-1192.
Fuller, JC; Arp, LH; Diehl, LM; Landin, KL; Baier, SM and Rathmacher, JA (2014). Subchronic toxicity study of b-hydroxy-b-methyl butyric free acid in Sprague Dawley rats. Food Chem. Toxicol., 67: 145-153.
Fuller, JC; Sharp, RL; Angus, HF; Khoo, PY and Rathmacher, JA (2015). Comparison of availability and plasma clearance rates of β-hydroxy-β-methyl butyrate delivery in the free acid and calcium salt forms. Br. J. Nutri., 114: 1403-1409.
Gallagher, PM; Carrithers, JA; Goodard, MP; Schulze, KE and Trappe, SW (2000). β-Hydroxy-β-methyl butyrate ingestion, Part II: Effects on hematology, hepatic and renal function. Med. Sci. Sports Exerc., 32: 2116-2119.
Gerlinger-Romero, F; Guimarães-Ferreira, L; Giannocco, G and Nunes, MT (2011). Chronic supplementation of beta-hydroxy-beta methyl butyrate (HMB) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats. Growth Horm. IGF Res., 21: 57-62.
Helen, J; Mukerji, P and Michael, J (2005). Tisdale attenuation of proteasome-induced proteolysis in skeletal muscle by beta-hydroxy-beta-methyl butyrate in cancer-induced muscle. Loss. Cancer Res., 65: 277-283.
Holecek, M; Muthny, L; Kovarik, M and Sispera, L
(2009). Effect of beta-hydroxy-beta-methyl butyrate (HMB) on protein metabolism in whole body and in selected tissues. Food and Chem. Toxicol., 47
Janero, DR (1990). Malondialdihyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Radic. Biol. Med., 9: 515-540.
Khudair, IM and Al-Hussary, NA (2010). Effect of vaccination on some biochemical parameters in broiler chickens. Iraqi J. Vet. Sci., 24: 59-64.
Kondo, H; Yumoto, K; Alwood, JS; Mojarrab, R; Wang, A; Almeida, EA; Searby, ND; Limoli, CL and Globus, RK (2010). Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse. J. Appl. Physiol., 108: 152-161.
Kornasio, R; Riederer, I; Butler-Browne, G; Mouly, V; Uni, Z and Halevy, O (2009). β-hydroxy-β-methyl butyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways. Biochim. Biophys. Acta BBA-Mol. Cell Res., 1793: 755-763.
Mahfouz, MK; Zyan, KAM and Abdel-Hamid, HH (2016). Biochemical effect of β-hydroxy-β-methyl butyrate calcium and creatine supplementations on some blood parameters, pro-inflammatory cytokines and growth performance of broiler chicks. Benha Vet. Med. J., 30: 39-50.
Mandal, AK and Mount, DB (2015). The molecular physiology of uric acid homeostasis. Annu. Rev. Physiol., 77: 323-345.
Mauch, DH; Nagler, K; Schumacher, S; Goritz, C; Muller, EC; Otto, A and Pfrieger, FW (2001). CNS synapto-genesis promoted by glia-derived cholesterol. Science. 294: 1354-1357.
Moraes, R; Bavel, DV; Moraes, BS and Tibiriçá, E (2014). Effects of dietary creatine supplementation on systemic microvascular density and reactivity in healthy young adults. Nutrition J., 13: 115-124.
Mullur, R; Liu, YY and Brent, GA (2014). Thyroid hormone regulation of metabolism. Physiol. Rev., 94: 355-382.
Nissen, S and Abumrad, NN (1997). Role of the leucine metabolite β-hydroxy β-methyl butyrate (HMB). J. Nutrt. Biochem., 8: 300-311.
Nissen, S; Fuller, JC; Sell, J; Ferket, PR and Rives, DV (1994). The effect of β-hydroxy-β-methylbutyrate on growth, mortality, and carcass qualities of broiler chickens. Poult. Sci., 73: 137-155.
Nissen, S; Sharp, L and Panton, M (2000). B-hydroxy-beta-methyl butyrate (HMB) supplementation humans is safe and may decrease cardiovascular risk factors. Am. Soc. Nutri. Sci., 30: 1937-1945.
NRC (1994). National research council nutrent requirement for poultry. 9th Edn., USA, National Academy Press. PP: 19-26.
Ostaszewski, P; Kostiuk, S; Balasińska, B; Jank, M; Papet, I and Glomot, F (2000). The leucine metabolite 3-hydroxy-3-methylbutyrate (HMB) modifies protein turnover in muscles of laboratory rats and domestic chickens in vitro. J. Anim. Physiol. Anim. Nutr., 84: 1-8.
Pacher, P; Nivorozhkin, A and Szabo, C (2006). Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol. Rev., 58: 87-114.
Portal, S; Zadik, Z; Rabinowitz, J; Pilz-Burstein, R; Adler-Portal, D and Meckel, Y (2011). The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebo-controlled study. Eur. J. Appl. Physiol., 111: 2261-2269.
Qiao, X; Zhang, HJ; Wu, SG; Yue, HY; Zuo, JJ; Feng, DY and Qi, GH (2013). Effect of β-hydroxy-β-methyl butyrate calcium on growth, blood parameters, and carcass qualities of broiler chickens. Poul. Sci., 92: 753-759.
Retiman, S and Frankel, S (1957). A colorimeteric method for determination of serum glutamic oxaloacetic pyruvic transaminase. Am. J. Clin. Path., 28: 56-63.
Robertson, SP; Twigg, SR; Sutherland-Smith, AJ; Biancalana, V; Gorlin, RJ; Horn, D; Kenwrick, SJ; Kim, CA; Morava, E; Newbury-Ecob, R; Orstavik, KH; Quarrell, OW; Schwartz, CE; Shears, DJ; Suri, M; Kendrick-Jones, J and Wilkie, AO (2003). Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans. Nat. Genet., 33: 487-491.
Rodwell, VW (2009). Metabolism of purine and pyrimidine nucleotides. Harper’s illustrated biochemistry.-28e. New York, McGraw Hill. PP: 30-292.
Routhier, DD and Stacy, JJ (2007). HMB use and its relationship to exercise-induced muscle damage and performance during exercise. Int. Sport Med. J., 2: 68-77.
Siu, PM; Pistilli, EE and Always, SE (2008). Age-dependent increase in oxidative stress in gastrocnemius muscle with unloading. J. Appl. Physiol., 105: 1695-1705.
Tako, E; Ferkt, PR and Uni, Z (2004). Effect of in vivo feeding on carbohydrate and beta-hydroxy-beta-methyl butyrate on the development of chick intestine. Poult. Sci., 83: 2023-2028.
Teitz, NW (1987). Fundamental of clinical chemistry. 2nd Edn., Philadelphia, PA, Saunders Co., PP: 47-53.
Van-Koevering, MT; Dolezal, HG; Gill, DR; Owens, FN; Strasia, CA; Buchanan, DS; Lake, R and Nissen, S (1994). Effects of beta-hydroxy-beta-methyl butyrate on performance and carcass quality of feedlot steers. J. Anim. Sci., 72: 1927-1935.
Wan, H; Zhu, J; Su, G; Liu, Y; HUa, L; HU, L; Wu, C; Zhang, R; Zhou, P; Shen, Y; Lin, Y; Xu, S; Fang, Z; Che, L; Feng, B and Wu, D (2016). Dietary supplementation with β-hydroxy-β-methyl butyrate calcium during the early postnatal period accelerates skeletal muscle fiber growth and maturity in intra-uterine growth-retarded and normal-birth-weight piglets. Br. J. Nutri., 115: 1360-1369.
Wang, CS; Chang, TT; Yao, WJ; Wang, ST and Chou, P
(2012). Impact of increasing alanine aminotransferase levels within normal range on incident diabetes. J. Formosan Med. Asso., 111: 201-208.
Wilkinson, DJ; Hossain, T; Hill, DS; Phillips, BE; Crossland, H; Williams, J; Loughna, P; Churchward-Venne, TA; Breen, L; Phillips, SM; Etheridge, T; Rathmacher, JA; Smith, K; Szewczyk, NJ and Atherton, PJ (2013). Effects of leucine and its metabolite β-hydroxy-β-methyl butyrate on human skeletal muscle protein metabolism. J. Physiol., 591: 2911-2923.
Witta, VC; Krause, GF and Bailey, ME (1970). A new extraction method for determination thiobarbituric acid values of pork and beef during storage. J. Food Sci., 35: 582-585.
Wu, H; Xia, Y; Jiang, J; Du, H; Guo, X; Liu, X; Li, C; Huang, G and Niu, K (2015). Effect of beta-hydroxy-beta-methyl butyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis. Arch. Gerontol. Geriatrics. 61: 168-175.