توزیع ناحیه‌ای و مخاطی برخی از سلول‌های اندوکراین ایمونو‌ری ‌اکتیو روده‌ای در خرگوش سفید نیوزلندی (Oryctolagus cuniculus L.)

نوع مقاله : مقاله کامل

نویسندگان

چکیده

هدف این مطالعه شناسایی توزیع مخاطی و ناحیه‌ای سلول‌های اندوکراین ترشح کننده گلوکاگون، سوماتوستاتین، (CCK-8) Chyholecystokinin-8، سراتونین، سکرتین، ماده P (SP) و هیستامین در روده کوچک و روده بزرگ خرگوش سفید نیوزلندی (Oryctolagus cuniculus L.) با روش ایمونوهیستوشیمی پراکسیداز-آنتی پراکسیداز (PAP) بود. مشخص شد که اکثر سلول‌های اندوکراین ایمونوری اکتیو (IR)، بیضی و دوکی شکل هستند و در بخش‌های قاعده‌ای غدد مربوطه قرار دارند. سلول‌های موجود در اپی تلیوم روده کوچک و بزرگ با لومن در ارتباط بوده ولی سلول‌هایی که در غدد قرار دارند به لومن روده‌ها دسترسی ندارند. سلول‌های ایمونوری اکتیو ترشح کننده گلوکاگون، سوماتوستاتین، سراتونین، سکرتین و ماده P در اپی تلیوم روده کوچک و بزرگ شناسایی شدند و مشاهده شد که سلول‌های ایمونوری اکتیو ترشح کننده هیستامین و ماده P به ندرت در سراسر روده گسترش یافته، اما بر خلاف آن‌ها سلول‌های ایمونوری اکتیو ترشح کننده سوماتوستاتین در سرتاسر روده گسترش یافته بودند. نتایج حاصل از این مطالعه ایمونوهیستوشیمی نشان داد که همانند سایر گونه‌های مهره‌داران، مجرای گوارش این گونه نیز حاوی انواع مختلفی از سلول‌های اندوکراین است که دارای توزیع و فراوانی منحصر به فرد وابسته به گونه است. ع و فراوانی منحصر به فرد وابسته به گونه است.

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