بررسی پارامترهای اکوکاردیوگرافی مدل سکته قلبی: مقایسه دو نژاد موش صحرایی

نوع مقاله : مقاله کامل

نویسندگان

چکیده

هدف از این مطالعه ایجاد مدل قلبی در دو نژاد لوئیس و ویستار، به عنوان نژاد درون‌زاد و برون‌زاد، و مقایسه پارامترهای اکوکاردیوگرافی آن‌ها قبل و بعد از ایجاد سکته قلبی و تعیین میزان مرگ و میر آن‌ها در اثر انجام این مدل است. در این مطالعه مدل قلبی بر روی 46 موش صحرایی لوئیس و 34 موش صحرایی ویستار با انسداد رگ نزولی قدامی چپ (LAD) انجام شد. پارامترهای اکوکاردیوگرافی دو بعدی، روش خطی هدایت شده توسط روش دو بعدی و داپلر از نماهای پارا استرنال بلند و کوتاه محور و نمای چهار حفره‌ای Apical ثبت شد. پارامترهای مورد بررسی ابعاد سپتوم داخلی بطنی دیاستولی و سیستول (IVSd, s)، قطر داخلی بطن چپ در دیاستول و سیستول (LVIDd, s) T ابعاد دیواره خلفی بطن چپ در دیاستول و سیستول (LVPWd, s)، کسر جهشی یا کسر تخلیه (EF) و کوتاهی کسری (FS) بود. تغییرات معنی‌دار در ابعاد سپتوم داخلی بطنی سیستولی، قطر داخلی بطن چپ در دیاستول و کسر جهشی و کوتاهی کسری قبل و بعد از سکته قلبی مشاهده شد و تفاوت معنی‌داری در پارامترها بین دو نژاد مشاهده نشد. میزان مرگ و میر برای نژاد لوئیس 51% که شامل مرگ و میر در اثر بیهوشی نیز بود که نسبت به 34% در ویستار قابل ملاحظه بود. گرچه پارامترهای اکوکاردیوگرافی بین دو نژاد مشابه است اما بر اساس مرگ و میر نژاد ویستار برای ایجاد مدل قلبی مقاومتر است.

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