Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Noncompartmental analysis of the data indicated that tetracycline has a half-life of 4.4 h, a body clearance of around 0.7 ml/kg.min and a volume of distribution of about 0.3 L/kg. The pharmacokinetics of tetracycline found in this study is favourable for therapeutic use in the dog.
Rajaian, H., Fazeli, M., & Jalaee, J. (2008). Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs. Iranian Journal of Veterinary Research, 9(3), 266-270. doi: 10.22099/ijvr.2008.1735
MLA
H. Rajaian; M. Fazeli; J. Jalaee. "Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs". Iranian Journal of Veterinary Research, 9, 3, 2008, 266-270. doi: 10.22099/ijvr.2008.1735
HARVARD
Rajaian, H., Fazeli, M., Jalaee, J. (2008). 'Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs', Iranian Journal of Veterinary Research, 9(3), pp. 266-270. doi: 10.22099/ijvr.2008.1735
VANCOUVER
Rajaian, H., Fazeli, M., Jalaee, J. Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs. Iranian Journal of Veterinary Research, 2008; 9(3): 266-270. doi: 10.22099/ijvr.2008.1735
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