Six mixed-breed apparently healthy dogs were intravenously administered a single dose of tetracycline hydrochloride (50 mg/kg) to evaluate the pharmacokinetic parameters of the drug. Blood samples were collected before and at various time intervals after the administration of the drug. Serum tetracycline concentrations were determined over a 24 h period using fluorescence spectrophotometry. Noncompartmental analysis of the data indicated that tetracycline has a half-life of 4.4 h, a body clearance of around 0.7 ml/kg.min and a volume of distribution of about 0.3 L/kg. The pharmacokinetics of tetracycline found in this study is favourable for therapeutic use in the dog.
Rajaian, H., Fazeli, M., Jalaee, J. (2008). Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs. Iranian Journal of Veterinary Research, 9(3), 266-270. doi: 10.22099/ijvr.2008.1735
MLA
H. Rajaian; M. Fazeli; J. Jalaee. "Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs". Iranian Journal of Veterinary Research, 9, 3, 2008, 266-270. doi: 10.22099/ijvr.2008.1735
HARVARD
Rajaian, H., Fazeli, M., Jalaee, J. (2008). 'Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs', Iranian Journal of Veterinary Research, 9(3), pp. 266-270. doi: 10.22099/ijvr.2008.1735
VANCOUVER
Rajaian, H., Fazeli, M., Jalaee, J. Pharmacokinetics of tetracycline hydrochloride after single intravenous injection in dogs. Iranian Journal of Veterinary Research, 2008; 9(3): 266-270. doi: 10.22099/ijvr.2008.1735