1Department of Biology, College of Sciences, University of Tehran, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran
3Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran
4Department of Biotechnology, International Center for Science and High Technology and Environmental Sciences, Mahan, Iran
Oxyntomodulin (OXM), a proglucagon-derived peptide, is a well known anorexigenic peptide found in the gut and brain of mammals. The present study was carried out to investigate the central effect of OXM on food intake in non-fasted and fasted Ross broiler chicks. At four weeks of age, a guide cannula was stereotaxically implanted into the right lateral ventricle of each bird. Two experiments were conducted on free-feeding (non-fasted) and 6-h fasted broilers. In each experiment, eight birds were used in a replicated 4 × 4 Latin square design. The birds were given an intracerebroventricular (ICV) injection of different doses of mammalian OXM. Intracerebroventricular injection of OXM at doses of 1.5, 3 and 6 nmol significantly (P<0.05) decreased food intake for 3 h post injection in both non-fasted and fasted chicks. It may be concluded that central OXM may exert a suppressive effect on food intake in chicks.