TY - JOUR ID - 175 TI - Central effect of mammalian oxyntomodulin on food intake in non-fasted and fasted chicks JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - Ghazanfari Moghaddam, A. AU - Jonaidi, H. AU - Abbasnejad, M. AU - Yaghoobi, M. M. AU - Sepehri, H. AD - Department of Biology, College of Sciences, University of Tehran, Tehran, Iran AD - Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran AD - Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran AD - Department of Biotechnology, International Center for Science and High Technology and Environmental Sciences, Mahan, Iran Y1 - 2010 PY - 2010 VL - 11 IS - 1 SP - 51 EP - 55 KW - Oxyntomodulin KW - Food intake KW - Intracerebroventricular injection KW - Chick DO - 10.22099/ijvr.2010.175 N2 - Oxyntomodulin (OXM), a proglucagon-derived peptide, is a well known anorexigenic peptide found inthe gut and brain of mammals. The present study was carried out to investigate the central effect of OXM onfood intake in non-fasted and fasted Ross broiler chicks. At four weeks of age, a guide cannula wasstereotaxically implanted into the right lateral ventricle of each bird. Two experiments were conducted onfree-feeding (non-fasted) and 6-h fasted broilers. In each experiment, eight birds were used in a replicated 4 × 4 Latin square design. The birds were given an intracerebroventricular (ICV) injection of different doses of mammalian OXM. Intracerebroventricular injection of OXM at doses of 1.5, 3 and 6 nmol significantly(P<0.05) decreased food intake for 3 h post injection in both non-fasted and fasted chicks. It may beconcluded that central OXM may exert a suppressive effect on food intake in chicks. UR - https://ijvr.shirazu.ac.ir/article_175.html L1 - https://ijvr.shirazu.ac.ir/article_175_8b48ea7e5a6ad8b9ccdcb61f61777d68.pdf ER -