Unusual histopathological features of a uterine leiomyosarcoma in a dog

Document Type : Scientific report

Authors

1 MVSc in Veterinary Surgery, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia

2 Ph.D. in Veterinary Surgery, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia

3 DVM, KM Global Animal Hospital, 5 Jalan Industri Batu Caves, 1/1, Taman Perindustrian Batu Caves, Selangor, Malaysia

4 Department of Veterinary Laboratory Diagnosis, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia

5 Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia

Abstract

Background: Uterine leiomyosarcoma is a malignant neoplasm arising from leiomyocytes in the uterus. Case description: A 12-year-old mixed-breed intact female dog was presented with vaginal bleeding for the past 2 weeks. Abdominal ultrasonography revealed a mixed echogenic mass in the uterus, and right lateral abdominal radiography showed a large mid-abdominal mass. Exploratory celiotomy was performed, revealing a solid mass in the entire uterine body and both uterine horns. Ovariohysterectomy was performed and the uterine mass sample was microscopically examined. Findings/treatment and outcome: The mass was composed of a dense proliferation of neoplastic cells that display two morphologic features; spindloid and epithelioid appearances. Additionally, chondroid-like matrix was noted. Both components were negative for cytokeratin AE1/AE3, and strongly positive for vimentin. The spindloid component was strongly positive for α-SMA, while the epithelioid-like component was moderately positive for alpha-smooth muscle actin. These findings are suggestive of a leiomyosarcoma. Although the recovery immediately following surgery was smooth and without complications, the dog’s condition worsened over the following month, ultimately leading to euthanasia. Conclusion: This report describes the histopathologic features and clinical outcome of an unusual variant of uterine leiomyosarcoma in a dog.

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References

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