An occurrence of intestinal histoplasmosis in a goat flock

Document Type : Scientific report

Authors

Department of Veterinary Pathology, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Orathanadu, Thanjavur, Tamil Nadu, India

Abstract

Background: The paper describes the first documentary evidence of intestinal histoplasmosis in Indian goats. Case description: A goat flock in delta region of Tamil Nadu with a report of mortality of eight animals with the history of inappetence, constipation, tenesmus and hematochezia. Three goat carcasses were presented for necropsy. Findings/treatment and outcome: Postmortem examination showed mesenteric lymphadenomegaly with greyish yellow viscous contents. Ileum contained scattered dark brownish tubular concretions inside the lumen. Colon and caecum had scattered firm serosal and mucosal nodules with caseous exudate. Lumen contained viscous haemorrhagic content. Mucosa of the colon showed numerous tiny ulcers. Urinary bladder serosa showed a focal firm nodule with caseous exudate and irregular firm mass. Microscopically, lung revealed oval inclusions with clear halo in pulmonary macrophages. Caecum and colon showed ulcers with necrotic core. Necrotic border showed multinucleated giant cells and oval bodies with clear halo. Mesenteric lymph node and urinary bladder revealed pyogranulomatous inflammation with aggregation of macrophages filled with numerous tiny inclusions. Periodic acid-Schiff and Grocott’s methanamine silver staining techniques and morphological features of the inclusion confirmed it as Histoplasma capsulatum. The case showed a resemblance with human colonic histoplasmosis. Conclusion: This report documents the first incidence of intestinal histoplasmosis in goats. Interestingly, the intestinal form of histoplasmosis is considered to be common in humans and it showed similarity with human disease in goats based on the gross and microscopic lesions.

Keywords

Main Subjects

References

Acharyya, BC; Acharyya, S and Chakrabarty, H (2021). Isolated gastrointestinal histoplasmosis: A rare diagnosis of pediatric chronic abdominal pain. Indian J. Pathol. Microbiol., 64: 827-830.
Alsibai, DK; Couppie, P; Blanchet, D; Adenis, A; Epelboin, L; Blaizot, R; Louvel, D; Djossou, F; Demar, M and Nacher, M (2020). Cytological and histopathological spectrum of histoplasmosis: 15 years of experience in French Guiana. Front. Cell Infect. Microbiol., 10: 591974.
Anderson, BR; Marriott, J; Bulathsinghala, C; Anjum, H and Surani, S (2018). Gastrointestinal histoplasmosis presenting as an acute abdomen with Jejunal perforation. Case Rep. Med., 2018: 8923972.
Bahr, NC; Antinori, S; Wheat, LJ and Sarosi, GA (2015). Histoplasmosis infections worldwide: thinking outside of the Ohio River valley. Curr. Trop. Med. Rep., 2: 70-80.
Bancroft, JD and Layton, C (2019). The hematoxylins and eosin. In: Suvarna, SK; Layton, C and Bancroft, JD (Eds.), Bancroft’s theory and practice of histological techniques. (8th Edn.), UK, Elsevier. PP: 126-138.
Bhinder, J; Mori, A; Cao, W and Malieckal, A (2018). A case of isolated gastrointestinal histoplasmosis. Cureus. 10: e2951.
Brandao, J; Woods, S; Fowlkes, N; Leissinger, M; Blair, R; Pucheu-Haston, C; Johnson, J; Elster Phillips, C and Tully, T (2014). Disseminated histoplasmosis (Histoplasma capsulatum) in a pet rabbit: case report and review of the literature. J. Vet. Diagn. Investig., 26: 158-162.
Bromel, C and Sykes, JE (2005). Histoplasmosis in dogs and cats. Clin. Tech. Small Anim. Pract., 20: 227-232.
Cano, MV and Hajjeh, RA (2001). The epidemiology of histoplasmosis: a review. Semin. Respir. Infect., 16: 109-118.
Chavez-Peon Berle, E; KuKanich, K and Biller, D (2020). Ultrasonographic findings of gastrointestinal histoplasmosis in dogs. Vet. Radiol. Ultrasound., 62: 108-115.
Cridge, H; Brinkman, E and Lathan, P (2019). Biliary dilatation: An unusual presentation of Histoplasma capsulatum in a dog. J. Am. Anim. Hosp. Assoc., 56: 285.
De Monbreun, WA (1939). The dog as a natural host for Histoplasma capsulatum. Am. J. Trop. Med. Hyg., 19: 565-587.
Fortin, JS; Calcutt, MJ; Nagy, DW and Kuroki, K (2017). Intestinal histoplasmosis in a captive reindeer (Rangifer tarandus), Missouri, USA. J. Zoo. Wildl. Med., 48: 925-928.
Guillot, J; Guerun, C and Chermette, R (2018). Histoplasmosis in animals. In: Seyedmousavi, S (Ed.), Emerging and epizootic fungal infections in animals. (1st Edn.), Cham, Switzerland, Springer International Publishing AG. PP: 115-128.
Heilmann, RM; Nabity, MB; Bryan, LK; Cook, AK and Scott, K (2021). Mucocutaneous nasal histoplasmosis in an immunocompetent dog. BMC Vet. Res., 17: 1-9.
Jimenez-Rivera, E; Davila-Ruiz, EO; García-Manzano, RA; Santos-Chab, GA; Aguirre-Trejo, JM; Fabián, JF and Tafoya-Ramirez, F (2021). Intestinal histoplasmosis in immunocompetent patient: An unusual cause of massive small intestine bleeding. Rev. Med. Hosp. Gen (Mex), 84: 123-128.
Lamps, LW; Molina, CP; West, AB; Haggitt, RC and Scott, MA (2000). The pathologic spectrum of gastrointestinal and hepatic histoplasmosis. Am. J. Clin. Pathol., 113: 64-72.
Layton, C and Bancroft, JD (2019). Carbohydrates. In: Suvarna, SK; Layton, C and Bancroft, JD (Ed.), Bancroft’s theory and practice of histological yechniques. (8th Edn.), UK, Elsevier. PP: 181-184.
Mitchell, M and Stark, DR (1980). Disseminated canine histoplasmosis: A clinical survey of 24 cases in Texas. Can. Vet. J., 21: 95-100.
Morris, GB; Ridgway, EJ and Suvarna, SK (2019). Traditional stains and modern techniques for demonstrating microorganisms in histology. In: Suvarna, SK; Layton, C and Bancroft, JD (Eds.), Bancroft’s theory and practice of histological techniques. (8th Edn.), UK, Elsevier. PP: 266-268.
Norton, SA (1994). Deep fungal skin diseases. In: James, WD (Ed.), Military dermatology. Textbook of military medicine - Part 3, Disease and the environment. (1st Edn.),
Washington D.C., Department of the Army. PP: 1-40.
Psarros, G and Kauffman, CA (2007). Colonic histoplasmosis: a difficult diagnostic problem. Gastroenterol. Hepatol., 3: 461-463.
Schlemmer, SN; Fratzke, AP; Gibbons, P; Porter, BF; Mansell, J; Ploeg, RJ; Rodrigues Hoffmann, A; Older, CE and Clark, SD (2019). Histoplasmosis and multicentric lymphoma in a Nubian goat. J. Vet. Diagn. Invest., 31: 770-773.
Schumacher, LL; Love, BC; Ferrell, M; De Silva, U; Fernando, R and Ritchey, JW (2013). Canine intestinal histoplasmosis containing hyphal forms. J. Vet. Diagn. Invest., 25: 304-307.
Sharma, R; Lipi, L; Gajendra, S; Mohapatra, I; Goel, RK; Duggal, R; Mishra, SR and Gautam, D (2017). Gastrointestinal histoplasmosis: a case series. Int. J. Surg. Pathol., 25: 592-598.
Sircar, AD; Tran, MN; Vaidya, SA; Goldstein, EJC and Wheat, LJ (2023). Disseminated histoplasmosis in an immunosuppressed patient successfully treated with isavuconazole. BMJ Case Rep., 0: e253718.
Sumit, A; Kuldeep, AK; Syed Asif, H; Arun, N and Sharmila, D (2022). Disseminated histoplasmosis in HIV patients - Case series from a single tertiary care centre in India. AJIM., 10: 98-102.
Sumithra, TG; Chaturvedi, VK; Rai, AK; Sunita, SC; Siju, SJ; Remya, V and Susan, C (2013). A review and update on canine and feline histoplasmosis. Asian J. Anim. Res., 1: 14-26.
Vijayan, C; Suprakasan, S; Kumar, G; Nair, P and Jayapalan, S (2007). Primary mucocutaneous histoplasmosis presents as oral ulcer. Indian J. Dermatol. Venereol. Leprol., 73: 209-211.

Files

Share

How to cite

Statistics