Pentraxin-3, endothelin-1, some biochemical parameters and hematology in bovine respiratory disease complex

Document Type : Full paper (Original article)


1 Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey

2 Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey

3 3Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey

4 Department of Virology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, 15100, Burdur, Turkey

5 Ph.D. Student in Microbiology, Department of Microbiology, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey

6 Ph.D. Student in Internal Medicine, Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey

7 Ph.D. Student in Surgery, Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey

8 Department of Microbiology, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey

9 Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey

10 Department of Surgery, Faculty of Veterinary Medicine, Kafkas University, 36100, Kars, Turkey


Background: Infectious bovine respiratory disease complex (BRDC) is one of the world’s major livestock problems. Aims: The study aimed to determine the diagnostic importance of pentraxin-3, endothelin-1, clinical biochemistry, and hematological parameters in infectious BRDC. Methods: Animals in this study were Simmental breed, 1-7 years old, untreated, and healthy and BRDC cattle (40 cattle with BRDC in the disease group, and 10 healthy cattle in the control group). Clinical findings such as general posture, respiratory rate per minute, rectal temperature, heart rate per minute, and mental posture of the diseased cattle were recorded. Blood samples were taken from the jugular vein only once from all cattle. Complete blood count from blood samples was measured in an automatic complete blood count device, biochemical parameters in an autoanalyzer, and pentraxin-3 and endothelin-1 were measured by ELISA method. Results: Rectal temperature, respiratory and pulse rates per minute, total leukocyte count, gamma-glutamyl transferase, urea, total bilirubin, lactate dehydrogenase, creatine kinase, pentraxin-3 and endothelin-1 concentrations were found to be statistically higher in BRDC group than those in the control group (P<0.001). Conclusion: Pentraxin-3 and endothelin-1 levels were statistically significantly higher in the BRDC group compared to the control group. As a result, pentraxin-3 and endothelin-1 were found to be diagnostically important in cattle diagnosed with BRDC.


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