Coincidence of meibomian adenoma and squamous cell carcinoma in the upper eyelid of a sheep: histopathological and immunohistochemical studies

Document Type : Scientific report

Authors

1 Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2 Graduated from Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

3 Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Abstract

This report is related to a female 7-year-old crossbreed sheep whose right eye had been protruded and
swelling of upper eyelid was observed. Routine enucleating was performed. Histopathological evaluation of
eyelid revealed coincidence of two kinds of neoplasms. The first part was composed of multiple lobules of
sebocytes, which were detected as meibomian adenoma. The second section included infiltrating islands of
neoplastic squamous epithelium extending through the basal lamina of the epithelium with keratin pearls and was noted as grade I squamous cell carcinoma. Immunohistochemical study of cytokeratin showed positive reaction in both kinds of neoplastic cells. This is a rare case of meibomian adenoma in sheep with squamous cell carcinoma coincidence.

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