Three dimensional modeling and quantitative analysis of long bone parameters on rabbit using micro computed tomography

Document Type : Short paper

Author

Department of Anatomy, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey

10.22099/ijvr.2021.39092.5688

Abstract

Background: Micro-computed tomography (µCT), a modern imaging technique, provides detailed information on the bone morphology of small animal models. Aims: The objectives are 1) to produce three dimensional (3D) models from micro-computed tomography (µCT) images of femoral and tibial bones of New Zealand rabbits, 2) estimate and compare morphometric and volumetric results among genders as well as left and right sides. Methods: A total of twenty (ten females, ten males, aged 12–18 week, weight=2.5–3 kg) adult New Zealand rabbits were used for this study. 3D reconstructed models of the femoral and tibial bones of rabbits were created from cross-sectional images of µCT by using the 3D Slicer program. Anatomical structures were determined on these 3D bone models. Afterward, morphometric parameters such as length, thickness, and width of various parts of the bones with volume and volume ratio values of cortical bone, trabecular bone, and medullary cavity were calculated. Results: The gender*laterality interaction term was found statistically significant in femoral diaphysis diameter, internal femoral diaphysis diameter, femoral head diameter, tibial diaphysis diameter, tibial distal width, and tibial proximal width measurements (P<0.001). The gender*laterality interaction term was not found to be significant in volume and volume fraction values of cortical bone, trabecular bone, and medullary cavity (P>0.05). Conclusion: It is thought that the study will contribute to the orthopedic experimental studies of rabbits for femoral and tibial bones and bring a modern perspective to the field of veterinary anatomy.

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Iranian Journal of Veterinary Research

Articles in Press, Accepted Manuscript
Available Online from 21 February 2021

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