Antibiotic resistance profiles of Salmonella serotypes isolated from animals in Iran: a meta-analysis

Document Type : Full paper (Original article)

Authors

1 Department of Microbiology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran

2 Student Research Committee, School of Medicine, Shahid Saddoughi University of Medical Sciences, Yazd, Iran

3 Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran, and Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

4 Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

10.22099/ijvr.2020.36252.5296

Abstract

Background: Salmonella infection (salmonellosis) is a zoonotic bacterial disease. Widespread use of antibiotics in livestock and poultry production for different purposes such as treatment and growth promotion has led to the emergence of antibiotic-resistant Salmonella, causing treatment of Salmonella infections more difficult with each passing year. Aims: To determine the antibiotic resistance prevalence of Salmonella serotypes isolated from animals in different provinces of Iran. Methods: To find eligible articles, we searched the international and national electronic databases using appropriate keywords in English and Persian. Results: After applying predefined criteria, 54 articles reporting antibiotic resistance profiles of Salmonella serotypes were included. Salmonella isolates were mostly resistant against nalidixic acid (67%), tetracycline (66.9%), and streptomycin (49.6%), followed by trimethoprim/sulfamethoxazole (41.6%) and kanamycin (23.6%). The highest sensitivity was observed against imipenem, meropenem, and cefepime with 1.7%, 1.4%, and 1.9% of all isolates being resistant, respectively. Conclusion: Results revealed that the prevalence of resistant isolates to nalidixic acid, tetracycline and streptomycin is high and their use must be restricted. In addition, resistance to other antibiotics such as chloramphenicol, ampicillin, cephalothin, cefixime, and enrofloxacin is at an alarming level that calls for attention in the future infection control and antibiotic stewardship programs.

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