Cardiorespiratory effects of epidurally administered ketamine or lidocaine in dogs undergoing ovariohysterectomy surgery: a comparative study

Document Type : Full paper (Original article)


1 1Section of Pharmacology and Veterinary Therapeutics, Department of Clinical Pharmacology and Veterinary Anesthesia, Faculty of Higher Studies Cuautitlan, National Autonomous University of Mexico, Cuautitlan Izcalli, Mexico State, 54714, Mexico

2 Department of Surgery, Faculty of Veterinary Medicine, National Autonomous University of Mexico, Mexico City, 04510, Mexico

3 Department of Canine Clinic, Faculty of Higher Studies Cuautitlan, National Autonomous University of Mexico, Mexico State, 54714, Mexico

4 Department of Biological Sciences, and Clinical Pharmacology and Veterinary Anesthesia, Faculty of Higher Studies Cuautitlan, National Autonomous University of Mexico, Cuautitlan Izcalli, Mexico State, 54714, Mexico

5 MSc Student in Neurology Area, Research Unit of Pediatric Hospital Century XXI, Mexican Social Security Institute, Mexico City, 06725, Mexico


Background: Analgesic and hemodynamic effects of ketamine in subanesthetic doses during surgical anesthesia and postoperative, are due to the action on the N-methyl-D-aspartate receptors (NMDAR). Aims: To evaluate the intraoperative cardiorespiratory effects provided by ketamine compared to lidocaine, both administered epidurally, in bitches submitted to ovariohysterectomy. Methods: Thirty-six dogs of different breeds were used in a randomized, prospective, and blinded clinical trial. Two groups were formed: GKET (ketamine 3 mg/kg, n=18) and GLIDO (lidocaine 4 mg/kg, n=18). Animals were premedicated with acepromazine 0.05 mg/kg intravenous. Anesthesia was induced with propofol 5 mg/kg intravenous. Anesthetic maintenance was performed with isoflurane in 100% oxygen. Every 5 min during surgery, heart rate (HR), respiratory rate (RR), esophageal temperature (°C), oxygen saturation (SPO2), end tidal carbon dioxide (ETCO2) and mean arterial pressure (MAP) were monitored. Results: Cardiorespiratory variables during anesthesia were within normal ranges. Heart rate was significantly higher at 5 (108 ± 12 vs 95 ± 11) and 10 (110 ± 11 vs 97 ± 11) min in GKET compared to GLIDO after the start of surgery (P=0.03 and P=0.01, respectively). Mean arterial pressure was higher in GKET, (100 ± 23, 105 ± 35, and 103 ± 35 mmHg) in comparison with GLIDO (66 ± 7, 74 ± 10, and 67 ± 9 mmHg) at 20, 25 and 30 min (P=0.01, P=0.004, and P=0.002, respectively). Mild hypothermia at 25 (36.5 ± 1.3°C) and 30 (36.5 ± 1.4°C) min in the GKET was recorded. Conclusion: Epidural administration of ketamine provides better hemodynamic stability, compared to the use of epidural lidocaine.


Main Subjects

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