Hepatocellular carcinoma in a sheep

Document Type : Scientific report


Department of Pathobiology, School of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran


At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×
15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecular
and solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells that
contain one or more large hyperchromatic bizarre-shaped nuclei scattered among clusters of neoplastic
hepatocytes. In addition, mitotic figures, dilated sinusoids and large vascular spaces filled with red blood
cells were observed in some sections. Based on gross and histopathologic characteristics, the mass was
diagnosed as hepatocellular carcinoma