Evaluation of topical application of honey in prevention of post-operative peritoneal adhesion formation in dogs

Document Type : Full paper (Original article)

Authors

1 Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Urmia, Urmia, Iran

2 Department of Pathobiology, Faculty of Veterinary Medicine, University of Urmia, Urmia, Iran

3 Graduated from Faculty of Veterinary Medicine, University of Urmia, Urmia, Iran

Abstract

The objective of this study was to determine the effectiveness of topical administration of honey in prevention of or reduction in post-surgical peritoneal adhesions in dog. The study was conducted on 18 adult
female mixed-breed dogs with a mean ± SD weight of 20 ± 4.25 kg. A standardized surgical trauma (serosal
trauma model) was made in the dogs’ descending colon to induce adhesion formation. The control group (n = 9) received saline treatment. In the experiment group (n = 9), the lesions were covered with honey. Three
weeks after laparotomy, the dogs were sacrificed and the adhesions were graded according to the Evans’s
scoring system. Overall, 67% (n = 6) of the control and 22% (n = 2) of the experiment animals presented
with moderate (grade-2) and severe (grade-3) adhesions. In the control group, there were 3 (33%) dogs with grade-0 or grade-1 adhesions, while in the experiment group there were 7 (78%) dogs with the same grades of adhesions. The difference between the two groups was significant (P<0.05). It was concluded that honey is a useful covering for damaged peritoneal surfaces and has high effectiveness in reducing post-operative adhesions.

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