Central effect of mammalian oxyntomodulin on food intake in non-fasted and fasted chicks

Document Type : Full paper (Original article)


1 Department of Biology, College of Sciences, University of Tehran, Tehran, Iran

2 Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran

3 Department of Biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman (SBUK), Kerman, Iran

4 Department of Biotechnology, International Center for Science and High Technology and Environmental Sciences, Mahan, Iran


Oxyntomodulin (OXM), a proglucagon-derived peptide, is a well known anorexigenic peptide found in
the gut and brain of mammals. The present study was carried out to investigate the central effect of OXM on
food intake in non-fasted and fasted Ross broiler chicks. At four weeks of age, a guide cannula was
stereotaxically implanted into the right lateral ventricle of each bird. Two experiments were conducted on
free-feeding (non-fasted) and 6-h fasted broilers. In each experiment, eight birds were used in a replicated 4 × 4 Latin square design. The birds were given an intracerebroventricular (ICV) injection of different doses of mammalian OXM. Intracerebroventricular injection of OXM at doses of 1.5, 3 and 6 nmol significantly
(P<0.05) decreased food intake for 3 h post injection in both non-fasted and fasted chicks. It may be
concluded that central OXM may exert a suppressive effect on food intake in chicks.