Effect of dietary Garcinia cambogia extract on serum lipid profile and serum enzymes in rats fed high-lipid diet

Document Type : Full paper (Original article)


1 Department of Biochemistry, Faculty of Veterinary Medicine, Istanbul University, Avcilar, 34310 Istanbul, Turkey

2 Department of Animal Nutrition and Nutritional Diseases, Faculty of VeterinaryMedicine, Istanbul University, Istanbul, Turkey


The aim of the study was to investigate the preventive effects of dietary Garcinia cambogia extract on
lipid metabolism and serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST)
and gamma-glutamyle transferase (GGT) in rats fed high-lipid diet. Thirty female, one-year-old Sprague-
Dawley rats were used and separated into three equal groups. Group 1 (control group) was fed basal diet (2%
liquid vegetable oil, 0% cholesterol), while the diets of both group 2 and 3 contained vegetable oil (2% liquid
and 5% hydrogenated vegetable oil) and cholesterol (3%). 4.5% (w/w) Garcinia cambogia extract was added
to the diet of group 3 from day 45. Blood samples were withdrawn from all rats on days 0, 45 and 75. Serum
levels of total protein, LDL-cholesterol and phospholipid were lower in the control group than in the other
two groups, and there were no significant differences between these two experimental groups at the end of
the study (Pgroup (group 3). HDL-cholesterol levels were significantly different between the three groups
(Pbetween the groups at the end of the study. Serum AST and GGT activities were significantly lower in the
groups 2 and 3 than those in the controls, respectively. Fat feeding caused rising lipid indices in serum, while
Garcinia cambogia supplementation to the fatty diet failed to decrease the rise in serum lipid indices in the
present dose. The higher doses of Garcinia cambogia extract should be investigated.