TY - JOUR ID - 614 TI - Effect of Garcinia cambogia extract on body weight gain, feed intake and feed conversion ratio, and serum non-esterified fatty acids and C-reactive protein levels in rats fed with atherogenic diet JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - Bilal, T. AU - Esen Gursel, F. AU - Ateş, A. AU - Altiner, A. AD - Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcilar, Istanbul, Turkey AD - Department of Biochemistry, Faculty of Veterinary Medicine, Istanbul University, 34320 Avcilar, Istanbul, Turkey Y1 - 2012 PY - 2012 VL - 13 IS - 4 SP - 330 EP - 333 KW - Body weight gain KW - CRP KW - Feed intake KW - Garcinia cambogia KW - NEFA DO - 10.22099/ijvr.2012.614 N2 - The aim of the study was to investigate the improving effect of Garcinia cambogia extract on performance metrics, and serum non-esterified fatty acids (NEFA) and C-reactive protein (CRP) levels in rats fed with atherogenic diet. Thirty, one-year-old, female Sprague-Dawley rats were randomly assigned to threeexperimental groups of ten animals each. Control group was fed with basal diet (2% liquid vegetable oil, 0%cholesterol), while the diets of groups 2 and 3 contained vegetable oil (2% liquid- and 5% hydrogenatedvegetable oil) and cholesterol (3%). 4.5% Garcinia cambogia was added to the diet of group 3 from day 45. Performance metrics were significantly lower in group 3 than the other groups. Serum NEFA levels were significantly higher in group 3 than the control group on day 45, and in group 3 compared with the other groups on day 75. Serum CRP levels were not significantly different among all groups in all days. In conclusion, the reduced performance metrics indicate that supplementation with Garcinia cambogia extractis a novel therapeutic tool for weight management. Also, this study indicates that large doses of Garciniacambogia can lead to a substantial increase in serum NEFA concentrations which may be due to theincreased fat degradation. UR - https://ijvr.shirazu.ac.ir/article_614.html L1 - https://ijvr.shirazu.ac.ir/article_614_074c6fd2c3780f89c391632075423d0e.pdf ER -