TY - JOUR ID - 5 TI - Zinc modulates heat-induced degenerative effects in mice testes JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - Babaei, H AU - Derakhshanfar, A AU - Kheradmand, A AU - Bazy, J AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran AD - Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran AD - Department of Clinical Sciences, College of Veterinary Medicine, University of Lorestan, Khorram Abad, Iran AD - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran; Y1 - 2007 PY - 2007 VL - 8 IS - 4 SP - 298 EP - 303 DO - 10.22099/ijvr.2007.5 N2 - This study was designed to investigate whether administration of zinc sulphate could improve theresponse of mouse testis to degenerative effects of short term exposure heating. Fifty-four adult male Balb/Cmice were anaesthetized and the scrotums of 36 of them were immersed for 15 min in a waterbath at 43°C.Immediately after the heating, half of the heated animals (n = 18) were injected with saline solution (HS) andthe other half (n = 18) were given 10 mg/kg of zinc sulphate intraperitoneally (HZ), and this was continuedevery other day for 60 days. Control group of mice (n = 18) were treated identical to the HS group with theexception that the waterbath was held at 23°C. Mice were sacrificed at 15, 30 and 60 days after heating andthe testes were gently excised. Seminiferous tubules diameter and percentage of spermatogenesis weremeasured in each testis. There was a significant reduction in the mean seminiferous tubules diameter and thepercentage of spermatogenesis up to day 30 after heating in the HS group in comparison with the controlgroup (172.5 ± 2.55 μm vs 208.2 ± 1.53 μm and 18.00 ± 0.77% vs 99.33 ± 0.33%, respectively) but in theHZ group, only initial decline (up to day 15) was observed in the mean seminiferous tubules diameter (199.1± 1.90 μm vs 206.0 ± 2.51 μm, not significant) and the percentage of spermatogenesis (91.33 ± 0.95% vs97.67 ± 0.66%, PHistopathological observations showed progressive degeneration up to day 30 after heating and then normalstructure was returned in the HS group. In the HZ group, normal structure was returned up to day 15. Theresults from this study indicated that administration of zinc sulphate may improve the spermatogenesisprocess after testicular damage caused by a short term exposure of the mouse testis to heat. UR - https://ijvr.shirazu.ac.ir/article_5.html L1 - https://ijvr.shirazu.ac.ir/article_5_1a4af6624980bdf7b83a7c4f4e293c73.pdf ER -