TY - JOUR ID - 3917 TI - The effects of sub-chronic administration of sub-lethal doses of amitraz/xylene on selected reproductive parameters of male Wistar rats JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - Omoja, V. U. AU - Anika, S. M. AU - Asuzu, I. U. AD - Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka Enugu State, Nigeria AD - Office of the Vice-Chancellor, Federal University Oye-Ekiti, Ekiti State, Nigeria Y1 - 2016 PY - 2016 VL - 17 IS - 4 SP - 277 EP - 280 KW - Amitraz KW - Rat KW - Sperm KW - Testis KW - Testosterone DO - 10.22099/ijvr.2016.3917 N2 - This study investigated the effects of sub-chronic administration of sub-lethal doses of amitraz on some testicular parameters of Albino rats. Twenty-four adult male Albino rats (100 ± 10 g) randomly assigned into four groups were used for the study. Groups A, B and C received 10.0, 2.0 and 0.4 mg/kg amitraz in 10 ml/kg water while group D received equivalent volume of water orally and daily for 84 days. Serum testosterone levels (TESL) were assessed on days 0, 28, 56 and 84. Epididymal sperm reserve (ESR), testicular sperm reserve (TSR), testicular weight index (TWI) and testicular histology were evaluated at the end of the experiment. Results revealed dose-dependent reduction (P<0.05) in the mean TESL, ESR and TSR in the amitraz-treated groups as the dose of the amitraz increased. Histological study revealed testicular degeneration characterized by depopulation of seminiferous tubules and depletion of the spermatogenic cells in rats in group A. It was concluded that sub-chronic administration of sub-lethal doses of amitraz could lead to reduced sperm quantity. UR - https://ijvr.shirazu.ac.ir/article_3917.html L1 - https://ijvr.shirazu.ac.ir/article_3917_15004cbae8bbecaba6384ba6d2e8b15d.pdf ER -