Assisted laparoscopic splenectomy: current concept for treatment of splenic hemangiosarcoma in dogs

Document Type : Full paper (Original article)

Authors

1 Department of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt

2 Department of Clinical Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt

3 Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt

4 Department of Animal Medicine (Internal Medicine), Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt

Abstract

Background: Hemangiosarcoma (HSA) is a common devastating malignant splenic tumor with high mortalities in dogs. Laparoscopic splenectomy (LS) is safe and gold standard technique for diseases required splenectomy. However, LS operation is a sensitive approach, which requires a restricted control for the vascular sealing procedures. Aims: We modified the LS technique through the application of hemostatic clips assisted-LS as an improved approach for the treatment of splenic HSA. Methods: Twelve dogs were admitted to the Veterinary Teaching Hospital, Zagazig University, Egypt for investigation of splenic HSA. Abdominal ultrasonography reveals the presence of large hypoechoic splenic masses with no further abnormalities within the peritoneal cavity. Thoracic radiographs, hematological assays, tumor necrosis factor-α (TNF-α) and histopathological investigations were done. Results: Hemostatic clips assisted-LS showed no major intra or post-operative complications. Laboratory analysis revealed anemia with an increase in TNF-α. Significant increase in platelets count with a slight increase in TNF-α was detected post-operative. Conclusion: Application of the improved hemostatic clips-assisted-LS is cost effective, with shorter operative time, feasible method for vessel sealing, as well as having few complications during the HAS treatment in dogs.

Keywords

Main Subjects

References

Aryazand, Y and Ashegh, H (2015). Laparoscopic assisted splenectomy in dogs: introducing the intracorporeal ligature placement technique. Iran. J. Vet. Surg., 10: 31-37.
Bojrab, MJ and Monnet, E (2010). Mechanisms of disease in small animal surgery. Teton NewMedia. https://www.ivis. org/library/mechanisms-of-disease-small-animal-surgery-3rd-edition.
Braun, U (2009). Ultrasonography of the gastrointestinal tract in cattle. The Veterinary Clinics of North America. Food Anim. Pract., 25: 567-590.
Bulus, H; Mahmoud, H; Altun, H; Tas, A and Karayalcin, K (2013). Outcomes of laparoscopic versus open splenectomy. J. Korean Surg. Soci., 84: 38-42.
Chaudhry, N; Khan, M; Kausar, S and Iqbal, K (1997). Experimental study on hemogram and chemistry profile in splenectomized dogs. Pakistan Vet. J., 17: 24-28.
Clifford, CA; Hughes, D; Beal, MW; Mackin, AJ; Henry, CJ; Shofer, FS and Sorenmo, KU (2001). Plasma vascular endothelial growth factor concentrations in healthy dogs and dogs with hemangiosarcoma. J. Vet. Int. Med., 15: 131-135.
Clifford, CA; Mackin, AJ and Henry, CJ (2000). Treatment of canine hemangiosarcoma: 2000 and beyond. J. Vet. Int. Med., 14: 479-485.
Cole, PA (2012). Association of canine splenic hemangiosarcomas and hematomas with nodular lymphoid hyperplasia or siderotic nodules. J. Vet. Diagn. Invest., 24: 759-762.
Collard, F; Nadeau, ME and Carmel, ÉN (2010). Laparoscopic splenectomy for treatment of splenic hemangiosarcoma in a dog. Vet. Surg., 39: 870-872.
Erridge, S; Payne, CJ and Sodergren, M (2019), Novel clip applicator for minimally invasive surgery. Surg. Endosc., 33: 2710-2718.
Gelmini, R; Romano, F; Quaranta, N; Caprotti, R; Tazzioli, G; Colombo, G; Saviano, M and Uggeri, F (2006). Sutureless and stapleless laparoscopic splenectomy using radiofrequency. Surg. Endosc., 20: 991-994.
Hodges, J and Christopher, MM (2011). Diagnostic accuracy of using erythrocyte indices and polychromasia to identify regenerative anemia in dogs. J. Am. Vet. Med. Assoc., 238: 1452-1458.
Khalaj, A; Bakhtiari, J and Niasari-Naslaji, A (2012). Comparison between single and three portal laparoscopic splenectomy in dogs. BMC Vet. Res., 8: 161.
Kim, JH; Graef, AJ; Dickerson, EB and Modiano, JF (2015). Pathobiology of hemangiosarcoma in dogs: research advances and future perspectives. Vet. Sci., 2: 388-405.
Martins, B; Torres, B; Rodriguez, A; Gamba, C; Cassali, G; Lavalle, G; Martins, G and Melo, E (2013). Clinical and pathological aspects of multicentric hemangiosarcoma in a Pinscher dog. Arq. Bras. Med. Vet. Zootec., 65: 322-328.
Ngetich, W; Okumu, A; Kitaa, J and Chepkirui, E (2017). Splenic hemangiosarcoma in a 10-year male German Shepherd dog: case report. Int. J. Vet. Sci. Res., 3: 054-057.
Richter, S (2006). Comparison of a reusable with a disposable device and effects of clamp surface geometry and structure. Surg. Endosc., 20: 890-894.
Rodgerson, DH and Hanson, RR (2000). Ligature slippage during standing laparoscopic ovariectomy in a mare. Can. Vet. J., 41: 395-397.
Slatter, DH (2003). Textbook of small animal surgery. 3rd Edn., Philadelphia, USA, Elsevier Health Sciences.
Spangler, WL and Culbertson, MR (1992). Prevalence, type, and importance of splenic diseases in dogs: 1,480 cases (1985-1989). J. Am. Vet. Med. Assoc., 200: 829-834.
Stedile, R; Beck, CA; Schiochet, F; Ferreira, MP; Oliveira, ST; Martens, FB; Tessari, JP; Bernades, SB; Oliveira, CS and Santos, AP (2009). Laparoscopic versus open splenectomy in dogs. Pesqui. Vet. Bras., 29: 653-660.
Suvarna, KS; Layton, C and Bancroft, JD (2019). Bancroft’s theory and practice of histological techniques E-Book. Elsevier Health Science. https://www.sciencedirect.com/ book/9780702068874/bancrofts-theory-and-practice-of-histological-techniques.
Wang, X and Lin, Y (2008). Tumor necrosis factor and cancer, buddies or foes? Acta Pharmacol. Sin., 29: 1275-1288.
Wright, T; Singh, A; Mayhew, PD; Runge, JJ; Brisson, BA; Oblak, ML and Case, JB (2016). Laparoscopic-assisted splenectomy in dogs: 18 cases (2012-2014). J. Am. Vet. Med. Assoc., 248: 916-922.

Files

Share

How to cite

Statistics