Estimation of Periostin as A Biomarker for Early Pregnancy Diagnosis in Goats: A Preliminary Study

Document Type : Full paper (Original article)


Hatay Mustafa Kemal University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, TR-31040, Hatay, Turkey



Bakground: Periostin is an extracellular matrix protein which plays an important role in the metastatic process and cancer cells migration. As implantation is similar mechanism to metastasis, it has been hypothetize that periostin may play a role in the implantation process. Aims: The aim of present study was to compare the periostin and progesterone level during early pregnancy stage in Damascus goats. Methods: Fourty goats were synchronized using progesterone based sponges and were inseminated upon estrus signs display. While ten goats (n=10) were kept as control and did not allowed to mate. The blood samples were taken through jugular venepuncture from control and synchronized goats at day of 13, 15, 17, 19 and 21 of breeding. Progesterone and periostin levels were determined by ELISA. Later the pregnancy diagnosis was confirmed by transabdominal ultrasonography on day 50th after mating. Results: Progesterone level was influenced by status of pregnancy and day of observation with an interaction status of pregnancy and day of observation in goats. Whereas, the periostin levels did not affected by status of pregnancy rather than the day of observation. Conclusion: Periostin level did not vary with progesterone level during phase of embryonic implantation in goats; however, standardization and application different procedures for periostin estimation in a large group of animals could be useful as an early pregnancy biomarker in goats.


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