Comparative evaluation of clinical efficiency of intramuscular diazepam-ketamine, medetomidine-ketamine, and xylazine-ketamine anaesthesia in Ring-necked pheasants (Phasianus colchicus)

Document Type: Full paper (Original article)

Authors

1 Department of Physiology, Faculty of Veterinary Medicine, Ondokuz Mayis University, 55139, Samsun, Turkey

2 Department of Surgery, Faculty of Veterinary Medicine, Ondokuz Mayis University, 55139, Samsun, Turkey

Abstract

Background: Several injectable anaesthetics and sedatives are used in various avian species for general anaesthesia. Birds are very sensitive animals and any mismanagement in a crisis can lead to immediate shock and death. Therefore, careful selection of the safest possible anaesthetic agent and dose is very important. Aims: The aim of this study was to examine the clinical efficiency of diazepam-ketamine (DK), medetomidine-ketamine (MK), and xylazine-ketamine (XK) combinations anaesthetic regimens in pheasants. Methods: Twenty-four pheasants were divided into three equal groups and received one of three anaesthetic combinations by intramuscular injections: 9.0 mg/kg diazepam and 150.0 mg/kg ketamine, 0.20 mg/kg medetomidine and 80.0 mg/kg ketamine, and 3.0 mg/kg xylazine and 80.0 mg/kg ketamine. Each pheasant was pre-medicated with sedative drugs and 5 min later, anaesthesia was induced with ketamine injection. Results: The weak time (2.50 ± 1.07 min; mean±SD) and down time (6.13 ± 1.25 min) were shortest in group XK. The sleep time was longest (73 ± 20.24 min) while the recovery time (157 ± 13.61 min) was shortest in group MK. Muscle relaxation was excellent during the anaesthesia in all groups. The recovery phase of the birds was uneventful. Heart rate (HR) in DK group was statistically higher than MK and XK groups. Body temperature (BT) decreased in all groups compared to baseline values and those of MK group were lower than DK and XK groups. Respiratory rate (RR) in XK group was significantly lower than DK and MK groups. Conclusion: In conclusion, the MK combination shows better anaesthetic outcome compared to DK or XK combinations in pheasants.

Keywords


Atalan, G; Uzun, M; Demirkan, I; Yildiz, S and Cenesiz, M (2002). Effect of medetomidine-butorphanol-ketamine anaesthesia and atipamezole on heart and respiratory rate and cloacal temperature of domestic pigeons. J. Vet. Med. A., 49: 281-285.
Capuano, SV; Lerche, NW and Valverde, CR (1999). Cardiovascular, respiratory, thermoregulatory, sedative, and analgesic effects of intravenous administration of medetomidine in rhesus macaques (Macaca mulatta). Lab. Anim. Sci., 49: 537-544.
Christensen, J; Fosse, RT; Halvorsen, OJ and Morild, I (1987). Comparison of various anesthetic regimens in the domestic fowl. Am. J. Vet. Res., 48: 1649-1657.
Curro, TG (1998). Anesthesia of pet birds. Sem. Avian Exo. Pet Med., 7: 10-21.
Durrani, UF; Khan, MA and Ahmad, SS (2008). Com-parative efficacy (sedative and anaesthetic) of detomidine, ketamine and detomidine-ketamine cocktail in pigeons (Columba livia). Paki. Vet. J., 28: 115-118.
Forbes, NA (1998). Avian anesthesia. Vet. Q.; 20: 265-266.
Gandomani, M; Ghashghaii, A; Tamadon, A; Auaran, HR; Behzadi, MA and Javdni, Z (2011). Comparison of anaesthetic effects of Ketamine-Xylazine and Ketamine-Diazepam combination in budgerigar. Vet. Scan., 6: 52-56.
Gunkel, C and Lafortune, M (2005). Current techniques in avian anesthesia. Sem. Avian Exo. Pet Med., 14: 263-276.
Hall, LW; Clarke, KW and Trim, CM (2001). Veterinary anaesthesia. (10th Edn.), England, W. B. Saunders, Harcourt Publishers Limited. PP: 472-475.
Kaya, M and Soylu, SM (2013). Analysis of electro-cardiographic parameters in the conscious common pheasants (Phasianus colchicus). Kafkas Univ. Vet. Fak. Derg., 19: 1039-1044.
Lichtenberger, M and Ko, J (2007). Anesthesia and analgesia for small mammals and birds. Vet. Clin. Exot. Anim., 10: 293-315.
Lierz, M andKorbel, R (2012). Anesthesia and analgesia in birds. J. Exot. Pet. Med., 21: 44-58.
Lumeij, J and Dennik, J (2003). Medetomidine-ketamine and diazepam-ketamine anaesthesia in racing pigeons (Columba livia domestica) a comparative study. J. Avian Med. Surg., 17: 191-196.
Machin, KL and Caulkett, NA (1998). Cardiopulmonary
effects of propofol and a medetomidine-midazolam-ketamine combination in mallard ducks. Am. J. Vet. Res., 59: 598-602.
Mahmud, MA; Shaba, P; Yisa, HY; Gana, J; Ndagimba, R and Ndagi, S (2004). Comparative efficacy of Diazepam, Ketamine, and Diazepam-Ketamine combination for sedation or anesthesia in cockerel chickens. J. Adv. Vet. Anim. Res., 1: 107-113.
Maiti, SK; Tiwary, R; Vasan, P and Dutta, A (2006). Xylazine, diazepam and midazolam premedicated ketamine anaesthesia in white leghorn cockerels for typhlectomy. J. S. Afr. Vet. Assoc., 77: 12-18.
McGrath, CJ; Lee, JC and Campbell, VL (1984). Dose-response anesthetic effects of ketamine in the chicken. Am. J. Vet. Res., 45: 531-534.
Morgan, CJ and Curran, HV (2012). Ketamine use: a review. Addiction. 107: 27-38.
Mostachio, GQ; de-Oliveira, LD; Carciofi, AC and Vicente WR (2008). The effects of anesthesia with a combination of intramuscular xylazine-diazepam-ketamine on heart rate, respiratory rate and cloacal temperature in roosters. Vet. Anaesth. Analg., 35: 232-236.
Muresan, C; Czirjak, GA; Pap, PL and Köbölkuti, LB (2008). Ketamine and xylazine anaesthesia in the house sparrow. Bulletin UASVM, Vet. Med., 65: 193-195.
Paul-Murphy, J and Fialkowski, J (2001). Injectable anesthesia and analgesia of birds. In: Gleed, R and Ludders, J (Eds.), Recent advances in veterinary anesthesia and analgesia: companion animals. (1st Edn.), Ithaca, NY, International Veterinary Information Service. E-Book: https://www.ivis.org/advances/Anesthesia_Gleed/paul/chapter.asp?LA=1, Last access date: 18.02.2019.
Sandmeier, P (2000). Evaluation of medetomidine for short-term immobilization of domestic pigeons (Columba livia) and Amazon parrots (Amazona species). J. Avian Med. Surg., 14: 8-14.
Sinclair, MD (2003). A review of the physiological effects of α-agonists related to the clinical use of medetomidine in small animal practice. Can. Vet. J., 44: 885-897.
Sinn, LC (1994). Anesthesiology. In: Ritchie, BW; Harrison, GJ and Harrison, LR (Eds.), Avian medicine: principles and application. (1st Edn.), Lake Worth, Wingers Publishing. PP: 1066-1080.
Uzun, M; Yildiz, S; Atalan, G; Kaya, M and Sulu, N (2003). Effects of medetomidine-ketamine combination anaesthesia on electrocardiographic findings, body temperature, and heart and respiratory rates in domestic pigeons. Turk. J. Vet. Anim. Sci., 27: 377-382.
Varner, J; Clifton, KR; Poulos, S; Broderson, JR and Wyatt, RD (2004). Lack of efficacy of injectable ketamine with xylazine or diazepam for anaesthesia in chickens. Lab. Anim., 33: 36-39.