Abnormal renovascular resistance in dogs with diabetes mellitus: correlation with glycemic status and proteinuria

Document Type : Full paper (Original article)

Authors

1 Animal Experimentation Station, Indian Veterinary Research Institute, Regional Campus, Bengaluru, Karnataka, 560024, India

2 Department of Clinics, Madras Veterinary College, TANUVAS, Chennai-600007, India

3 Department of Veterinary Clinical Medicine, Ethics and Jurisprudence, Madras Veterinary College, TANUVAS, Chennai-600007, India

Abstract

Present study was conducted with the objectives of determining the renal vascular resistance in dogs with diabetes mellitus and to study the correlation between the indices of renovascular resistance with glycemic status, systolic blood pressure (SBP) and proteinuria in dogs with diabetes mellitus. This study was conducted on seventeen diabetic dogs and ten apparently healthy dogs. Increased renal resistive index (RI) and pulsatility index (PI) were observed in diabetic dogs as compared to healthy dogs. Systemic hypertension and proteinuria were observed in 10 and 3 out of 17 diabetic dogs, respectively. Significant positive correlation was observed between the indices of renovascular resistance and fasting blood glucose levels and between the indices of renovascular resistance and serum glycated hemoglobin levels. No correlation was observed between the indices of renovascular resistance and SBP as well as the indices of renovascular resistance and proteinuria. As the indices of renovascular resistance correlate significantly with glycemic status, they can be used as the early marker for kidney damage in diabetic patients. Among these indices renal PI was found to be more sensitive than renal RI.

Keywords

References

Acierno, MJ and Labato, MA (2005). Hypertension in renal disease: diagnosis and treatment. Clin. Tech. Sm. Anim. Pract., 20: 23-30.
Arima, S and Ito, S (2003). The mechanisms underlying altered vascular resistance of glomerular afferentand efferent arterioles in diabetic nephropathy. Nephrol. Dial. Transpl., 18: 1966-1969.
Brown, S; Atkins, C and Bagley, R (2007). Guidelines for the identification, evaluation, and management of systemic hypertension in dogs and cats. J. Vet. Intern. Med., 21: 542-558.
Casadei, A; Floreani, M; Fanolla, A; Gaspa, U and Marchesi, M (2000). Renal doppler color ultrasonography in the study of diabetic nephropathy. Arch. Ital. Urol. Androl., 72: 205-210.
Colli, A; Cocciolo, M; River, C and Martinez, E (1993). Abnormal renovascularimpedence in patients with hepatic cirrhosis: detection with duplex ultrasonograpghy. Radiology. 187: 561-563.
Cruickshank, K; Riste, L; Anderson, SG; Wright, JS; Dunn, G and Gosling, RG (2002). Aorticpulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function. Circulation. 106: 2085-2090.
Davison, LJ; Herrtage, ME and Catchpole, B (2005). Study of 253 dogs in the United Kingdom with diabetes mellitus. Vet. Rec., 156: 467-471.
Dukes, J (1992). Hypertension: a review of the mechanisms, manifestations and management. J. Sm. Anim. Prac., 33: 119-129.
Ettinger, SJ and Feldman, EC (2005). Textbook of veterinary internal medicine. 6th Edn., St. Louis, Missouri, USA, Elsevier Saunders. P: 1716.
Fioretto, P and Mauer, M (2007). Histopathology of diabetic nephropathy. Semin. Nephrol., 27: 195-207.
Gaber, L; Walton, C; Brown, S and Bakris, G (1994). Effects of different antihypertensive treatments onmorphologic progression of diabetic nephropathy in uninephrectomized dogs. Kidney. Int., 46: 161-169.
Hayashi, K; Epstein, M; Loutzenheiser, R and Forster, H (1992). Impaired myogenic responsiveness of afferent arteriole in streptozotocin-induced diabetic rats: role of eicosanoid derangements. J. Am. Soc. Nephrol., 2: 1578-1586.
Heilig, CW; Concepcion, LA; Riser, BL; Freytag, SO; Zhu, M and Cortes, P (1995). Overexpression of glucose transporters in mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype. J. Clin. Invest., 96: 1802-1814.
Herring, IP; Panciera, DL and Were, SR (2014). Longitudinal prevalence of hypertension, proteinuria, and retinopathy in dogs with spontaneous diabetes Mellitus. J. Vet. Intern. Med., 28: 488-495.
Hoenig, M (2002). Comparative aspects of diabetes mellitus in dogs and cats. Mol. Cel. Endocrinol., 197: 221-229.
Hung-Yin, C; Yu-Hsin, L and Hui-Pi, H (2016). Association of renal resistive index, renal pulsatility index, systemic hypertension, and albuminuria with survival in dogs with pituitary-dependent hyperadrenocorticism. Intern. J. Endocrin., 2016: Article ID 3814034.
Ishimura, E; Nishizawa, Y; Kawagishi, T; Okuno, Y; Kogawa, K; Fukumoto, S; Maekawa, K; Hosoi, M; Inaba, M; Emoto, M and Morii, H (1997). Intrarenal hemodynamic abnormalities in diabetic nephropathy measured by duplex doppler sonography. Kid. Intern., 51: 1920-1927.
Koenhemsi, L; Toydemir, S; Ucmak, M; Gonul, R and Or, ME (2016). Evaluation of early renal disease in bitches with pyometra based on renal doppler measurements. Vet. Med. (Czech), 61: 344-347.
Kraft, W and Egner, B (2003). Causes and effects of hypertension. In: Egner, B; Carr, A and Brown, S (Eds.), Essential facts of blood pressure in dogs and cats. (3rd Edn.), Vet Verlag, Babenhausen. PP: 61-86.
Lin, CL; Wang, JY; Huang, YT; Kuo, YH; Surendran, K and Wang, FS (2006). Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells. J. Am. Soc. Nephrol., 17: 2812-2820.
Littman, MP (2005). Hypertension. In: Ettinger, S and Feldman, EC (Eds.), Textbook of veterinary internal medicine diseases of the dog and cat. (5th Edn.), Philadelphia, W. B. Saunders. PP: 179-182.
Miller, E (1995). Long-term monitoring of the diabetic dog and cat. Vet. Clin. North. Am.: Sm. Anim. Prac., 25: 571-584.
Munana, KR (2015). Long-term complications of diabetes mellitus. Part I: Retinopathy, nephropathy, neuropathy. Vet. Clin. North. Am.: Sm. Anim. Prac., 25: 715-730.
Novellas, R; Espada, Y and Gopegui, RR (2007). Doppler ultra-sonographic estimation of renal and ocular resistive and pulsatility indices in normal dogs and cats. Vet. Radiol. Ultrasound., 48: 69-73.
Novellas, R; Gopegui, RR and Espada, Y (2007). Increased renal vascular resistance in dogs with hepatic disease. Vet. J., 30: 1-5.
Novellas, R; Gopegui, RR and Espada, Y (2008). Determination of renal vascular resistance in dogs with diabetes mellitus and hyperadrenocorticism. Vet. Rec., 163: 592-596.
Patel, A (2007). Effects of a fixed combination of perindopril and indapamide on macrovascular andmicrovascular outcomes in patients with type 2 diabetes mellitus: a randomised controlled trial. Lancet., 370: 829-840.
Rivers, BJ; Walter, PA; Polzin, DJ and King, VL (1997). Duplex doppler estimation of intrarenal Pourcelot resistive index in dogs and cats with renal disease. J. Vet. Intern. Med., 11: 250-260.
Santha, K; Mahendran, BK; Perumal, KK; Inmozhi, R and Sethupathy, S (2017). Renal resistive index and its association with insulin resistance in patients with Type 2 Diabetes mellitus. IOSR J. Dental. Medical Sci., 16: 51-57.
Sari, A; Dinc, H; Zibandeh, A; Telatar, M and Gumele, HR
(1999). Value of resistive index in patients with clinical diabetic nephropathy. Invest. Radiol., 34: 718-721.
Struble, AL; Feldman, EC; Nelson, RW and Kass, PH (1998). Systemic hypertension and proteinuria in dogs with diabetes mellitus. J. Am. Vet. Med. Assoc., 213: 822-825.
Youssef, DM and Fawzy, FM (2012). Value of renal resistive index as an early marker of diabetic Nephropathy in children with Type-1 diabetes mellitus. Saudi. J. Kidney. Dis. Transpl., 23: 985-989.

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