Saif, R., Awan, A., Lyons, L., Gandolfi, B., Tayyab, M., Ellahi Babar, M., Wasim, M. (2016). Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world. Iranian Journal of Veterinary Research, 17(4), 231-236. doi: 10.22099/ijvr.2016.3907
R. Saif; A. R. Awan; L. Lyons; B. Gandolfi; M. Tayyab; M. Ellahi Babar; M. Wasim. "Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world". Iranian Journal of Veterinary Research, 17, 4, 2016, 231-236. doi: 10.22099/ijvr.2016.3907
Saif, R., Awan, A., Lyons, L., Gandolfi, B., Tayyab, M., Ellahi Babar, M., Wasim, M. (2016). 'Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world', Iranian Journal of Veterinary Research, 17(4), pp. 231-236. doi: 10.22099/ijvr.2016.3907
Saif, R., Awan, A., Lyons, L., Gandolfi, B., Tayyab, M., Ellahi Babar, M., Wasim, M. Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world. Iranian Journal of Veterinary Research, 2016; 17(4): 231-236. doi: 10.22099/ijvr.2016.3907
Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world
1Department of Biotechnology, Virtual University of Pakistan, Lahore, Pakistan
2Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan
3Department of Veterinary Medicine & Surgery, College of Veterinary Medicine, University of Missouri-Columbia, Columbia, MO 65211, USA
Abstract
Current research highlights the Hspb1 based screening of eight cat populations of the world to investigate the association of newly found locus within cat mammary tumors. Total 180 cats were screened on the basis of Hspb1 4 bp deletion locus (1514-1517del4) which was observed in six mammary tumor cases in Siamese cat breed. Case-control association study revealed the non-significance with P=0.201 and an overall mutant allele frequency of 0.30 ranging from 0.20-0.40 was observed in other cat populations. Similarly, HWE was also obeyed in combined population samples with P=0.860 and found non-significant with range of 0.429-0.708 in other non-Pakistani cat populations as well. These results might be helpful to understand the association of this novel locus in a better way with large sample size of cases and may also serve as a potential marker for mammary tumor diagnosis, particularly in cats and generally in all other animal populations in comparative genetics and genomics context.
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