1Department of Pathobiology, School of Veterinary Medicine, Lorestan University, Khorramabad, Iran
2Department of Animal Sciences, Faculty of Agriculture, Lorestan University, Khorramabad, Iran
3Department of Physiology, College of Veterinary Medicine, Ilam University, Ilam, Iran
This study was conducted to investigate the possible involvement of the histaminergic system in the mediation of ghrelin-induced feeding behavior in broiler chickens. In the trial 1, the effect of intracerebroventricular (ICV) injection of ghrelin on feed intake was examined in 3-h feed-deprived broiler chickens. In the trials 2 and 3, the chickens were received ICV chlorpheniramine (an H1 receptor antagonist) and cimetidine (an H2 receptor antagonist) prior to ghrelin injection, respectively. Cumulative feed intake was measured at 3-h post injections. Infusion of ghrelin (0.3, 0.6 and 1.2 nmol) decreased feed intake dosedependently (P<0.05). Pre-treatment of chlorpheniramine (100 μg) attenuated the inhibitory effect of ghrelin on feed intake (P<0.05), while such an effect was not noticed by pre-injection of cimetidine (100 μg). The results suggest that there is an interaction between ghrelin and the histaminergic system (through H1 receptors) on control of feed intake in broiler chickens.