Morphopathological study of naturally occurring ovine pulmonary adenocarcinoma in sheep in Fars province, Iran

Document Type: Full paper (Original article)

Authors

1 Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

2 Graduated from School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Abstract

Ovine pulmonary adenocarcinoma (OPA) is a contagious and transmissible lung cancer of sheep
resembling human bronchiolo-alveolar carcinoma. In the present study, lungs of 9400 sheep slaughtered in
Fars province, Iran were examined morphopathologically. The OPA was diagnosed in the lungs of 21
(0.22%) out of 9400 sheep. Frequency of involvement of different lobes in the affected lungs was included
apical lobe (62%), cardiac lobe (33%), middle lobe (33%), diaphragmatic lobe (62%) and accessory lobe
(5%). In 12 sheep, the classical form observed as firm, white to grayish coalescing masses mostly in the
cranio-ventral lobes associated with wet cut surface and frothy fluid in the airways. In 9 sheep, atypical
lesions observed as small clearly demarcated nodules mostly in diaphragmatic lobes associated with dry cut
surface and minor fluid in the airways. Histopathological changes were almost similar in the two forms. They
consisted of an acinar or papillary growth of neoplastic cells in the alveoli and polypoid proliferation of
bronchiolar epithelium. There were variable amounts of connective tissue, myxomatous foci and infiltration
of lymphocytes and plasma cells in the interstitial tissue of the affected alveoli. No metastatic lesion was
observed in the lymph nodes. The findings of this study show that atypical and classical forms represent
different stages or manifestations of a single disease spectrum.

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