TY - JOUR ID - 85 TI - Effects of aflatoxin B1 on profiles of gonadotropic (FSH and LH), steroid (testosterone and 17β-estradiol) and prolactin hormones in adult male rat JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - Hasanzadeh, Sh. AU - Hosseini, E. AU - Rezazadeh, L. AD - Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran AD - Graduated from Faculty of Veterinary Medicine, Urmia University, Urmia, Iran Y1 - 2011 PY - 2011 VL - 12 IS - 4 SP - 332 EP - 336 KW - Male rat KW - aflatoxin B1 KW - Pituitary hormones KW - Testosterone KW - 17β-estradiol DO - 10.22099/ijvr.2011.85 N2 - Aflatoxins (AFs) are natural contaminants of feed and feedstuffs, thus the study of the noxious effects ofthese agents on the male reproductive system is of outstanding importance. Our aim for this study is theevaluation of the effects of oral administration of aflatoxin B1 on the reproductive hormonal changes in adult male rat. Twenty eight Wistar strain male rats were selected for this study. The rats were divided into 4groups, viz, control (C), test groups (T1, T2, and T3). The toxin doses were prepared in sterile distilled waterat 0.8 ppm, 1.6 ppm, 3.2 ppm, and administered through oral gavages, 1 ml/animal/day to groups T1, T2, and T3, respectively for 48 days and each animal of group C was gavaged with 1 ml/day sterile distilled water. The hormonal assays were carried out using ELISA biochemical kits for serum FSH, LH, prolactintestosterone and 17β-estradiol. Results showed that, the levels of serum LH and testosterone were lower(P<0.001), but conversely the levels of FSH and prolactin were higher (P<0.001) in the test groups. The levelof 17β-estradiol was affected by significantly falling (P<0.01) only in group T3. We conclude that, the oraladministration of the aflatoxin B1 strictly alters the concentrations of FSH, LH, prolactin, and testosterone inmale Wistar rats. UR - https://ijvr.shirazu.ac.ir/article_85.html L1 - https://ijvr.shirazu.ac.ir/article_85_7fac07067a567ac2e94a0dfdd012c341.pdf ER -