TY - JOUR ID - 5448 TI - Cardiorespiratory effects of epidurally administered ketamine or lidocaine in dogs undergoing ovariohysterectomy surgery: a comparative study JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - Miranda-Cortés, A. E. AU - Ruiz-García, A. G. AU - Olivera-Ayub, A. E. AU - Garza-Malacara, G. AU - Ruiz-Cervantes, J. G. AU - Toscano-Zapien, J. A. AU - Hernández-Avalos,, I. AD - 1Section of Pharmacology and Veterinary Therapeutics, Department of Clinical Pharmacology and Veterinary Anesthesia, Faculty of Higher Studies Cuautitlan, National Autonomous University of Mexico, Cuautitlan Izcalli, Mexico State, 54714, Mexico AD - Department of Surgery, Faculty of Veterinary Medicine, National Autonomous University of Mexico, Mexico City, 04510, Mexico AD - Department of Canine Clinic, Faculty of Higher Studies Cuautitlan, National Autonomous University of Mexico, Mexico State, 54714, Mexico AD - Department of Biological Sciences, and Clinical Pharmacology and Veterinary Anesthesia, Faculty of Higher Studies Cuautitlan, National Autonomous University of Mexico, Cuautitlan Izcalli, Mexico State, 54714, Mexico AD - MSc Student in Neurology Area, Research Unit of Pediatric Hospital Century XXI, Mexican Social Security Institute, Mexico City, 06725, Mexico Y1 - 2020 PY - 2020 VL - 21 IS - 2 SP - 92 EP - 96 KW - analgesia KW - dog KW - epidural KW - ketamine KW - lidocaine DO - 10.22099/ijvr.2019.34065.5039 N2 - Background: Analgesic and hemodynamic effects of ketamine in subanesthetic doses during surgical anesthesia and postoperative, are due to the action on the N-methyl-D-aspartate receptors (NMDAR). Aims: To evaluate the intraoperative cardiorespiratory effects provided by ketamine compared to lidocaine, both administered epidurally, in bitches submitted to ovariohysterectomy. Methods: Thirty-six dogs of different breeds were used in a randomized, prospective, and blinded clinical trial. Two groups were formed: GKET (ketamine 3 mg/kg, n=18) and GLIDO (lidocaine 4 mg/kg, n=18). Animals were premedicated with acepromazine 0.05 mg/kg intravenous. Anesthesia was induced with propofol 5 mg/kg intravenous. Anesthetic maintenance was performed with isoflurane in 100% oxygen. Every 5 min during surgery, heart rate (HR), respiratory rate (RR), esophageal temperature (°C), oxygen saturation (SPO2), end tidal carbon dioxide (ETCO2) and mean arterial pressure (MAP) were monitored. Results: Cardiorespiratory variables during anesthesia were within normal ranges. Heart rate was significantly higher at 5 (108 ± 12 vs 95 ± 11) and 10 (110 ± 11 vs 97 ± 11) min in GKET compared to GLIDO after the start of surgery (P=0.03 and P=0.01, respectively). Mean arterial pressure was higher in GKET, (100 ± 23, 105 ± 35, and 103 ± 35 mmHg) in comparison with GLIDO (66 ± 7, 74 ± 10, and 67 ± 9 mmHg) at 20, 25 and 30 min (P=0.01, P=0.004, and P=0.002, respectively). Mild hypothermia at 25 (36.5 ± 1.3°C) and 30 (36.5 ± 1.4°C) min in the GKET was recorded. Conclusion: Epidural administration of ketamine provides better hemodynamic stability, compared to the use of epidural lidocaine. UR - https://ijvr.shirazu.ac.ir/article_5448.html L1 - https://ijvr.shirazu.ac.ir/article_5448_b576adcab52545b516b70d3263f7f2a6.pdf ER -