TY - JOUR ID - 5141 TI - Distribution and relative frequency of immunohistochemically detected endocrine cells in the stomach of New Zealand White rabbit (Oryctolagus cuniculus) JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - Türk, S. AU - Çınar, K. AU - Öztop, M. AD - Department of Biology, Faculty of Science and Art, Süleyman Demirel University, 32260, Isparta, Turkey AD - Department of Biology, Faculty of Science and Art, Mehmet Akif Ersoy University, 15100, Burdur, Turkey Y1 - 2019 PY - 2019 VL - 20 IS - 1 SP - 39 EP - 45 KW - Endocrine cells KW - Histamine KW - Immunoreactivity KW - New Zealand White rabbit KW - Serotonin DO - 10.22099/ijvr.2019.5141 N2 - Background: Gastrointestinal (GI) endocrine cells produce many GI hormones that perform various physiological functions of the digestive system. Aims: We aimed to investigate the presence and distribution of immunoreactive (IR) endocrine cells to glucagon, somatostatin, cholecystokinin-8 (CCK-8), serotonin, secretin and histamine in the stomach of adult male New Zealand White rabbit (Oryctolagus cuniculus). Methods: For immunohistochemical staining, peroxidase anti-peroxidase (PAP) method was applied to stomach samples. Results: Glucagon-IR cells of closed- and open type were found throughout all the stomach parts examined. Somatostatin-IR cells of closed- and open type in the cardiac and oxyntic glands were localized to deep portions of foveola gastrica. CCK-8 IR cells that were not observed in the cardia and fundus were mostly localized to the glands and lamina epithelialis in the pyloric part near the duodenum. Oval-shaped open and closed type serotonin-IR cells were mostly dispersed throughout the fundic and pyloric glands. Secretin-IR cells were rare in the pyloric and cardiac region although they were not observed in the fundic glands. Histamine-IR cells were rarely found in the cardia, fundus and pylorus. Conclusion: Our findings show that glucagon, histamine, somatostatin, secretin and serotonin might be produced by all the stomach regions while pyloric region had only CCK-8 IR. These distribution patterns also provide further evidence of species-specific differences, which might be important from the evolutionary aspect of the digestive tract in relation to evolutional niches and nutrient resources. UR - https://ijvr.shirazu.ac.ir/article_5141.html L1 - https://ijvr.shirazu.ac.ir/article_5141_d5485804aa1bb756aea96d65a79c4a4b.pdf ER -