TY - JOUR ID - 1985 TI - Association between bovine lactoferrin gene variant and somatic cell count in milk based on EcoRI restriction site JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - ‌Hemati Doust, V. AU - Rahimi-Mianji, G. AU - Farhadi, A. AD - Laboratory for Molecular Genetics and Animal Biotechnology, Faculty of Animal Science and Fisheries, Sari Agricultural Sciences and Natural Resources University, Sari, Iran Y1 - 2014 PY - 2014 VL - 15 IS - 1 SP - 62 EP - 65 KW - Lactoferrin KW - Somatic cell count KW - Polymorphism DO - 10.22099/ijvr.2014.1985 N2 - Mastitis is one of the most serious and costly diseases affecting dairy cattle production. In the present study, effects of a lactoferrin gene polymorphism (intron 6) on milk somatic cell count (SCC) and subclinical mastitis was investigated in 121 Holstein dairy cattle. Two alleles of A and B and two genotypes of AA and AB were found in an EcoRI recognized single nucleotide polymorphism in intron 6 of lactoferin gene with the frequencies of 85.12, 14.88, 70.25 and 29.75%, respectively. No homozygous BB cows were detected in the studied population. Marker-traits association analysis showed that EcoRI marker site in lactoferrin gene was significantly related to SCC (P≤0.01) with AB as a desirable genotype. The obtained results in the present study indicated that selection of the AB genotypes for EcoRI recognized single nucleotide polymorphism might contribute to a reduction of SCC in Holstein dairy cattle. UR - https://ijvr.shirazu.ac.ir/article_1985.html L1 - https://ijvr.shirazu.ac.ir/article_1985_4a866f8b711fff1c6de23a962603b5dc.pdf ER -