TY - JOUR ID - 1694 TI - Comparison of the effects of different doses of acepromazine-xylazine on the electrocardiogram in dogs JO - Iranian Journal of Veterinary Research JA - IJVR LA - en SN - 1728-1997 AU - Sarchahi, A. A. AU - Vesal, N. AU - Nikahval, B. AU - Karampour, A. AD - Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran AD - Ph.D. Student in Surgery, Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran AD - Graduated from School of Veterinary Medicine, Shiraz University, Shiraz, Iran Y1 - 2009 PY - 2009 VL - 10 IS - 3 SP - 208 EP - 215 KW - Acepromazine KW - Atropine KW - dog KW - Electrocardiogram KW - Xylazine DO - 10.22099/ijvr.2009.1694 N2 - Seventy seven adult large mixed breed dogs of either sex were included in this study. The animals were randomly divided into four groups and received the following drug combinations intramuscularly: Group 1 xylazine (0.5 mg/kg) and acepromazine (0.05 mg/kg), Group 2 xylazine (0.8 mg/kg) and acepromazine (0.03 mg/kg), Group 3 xylazine (0.3 mg/kg) and acepromazine (0.08 mg/kg) and Group 4 xylazine (0.5 mg/kg) acepromazine (0.05 mg/kg) and atropine (0.04 mg/kg). Results showed no significant differences in the Pwave and QRS complex durations, PR interval and R waves among the 4 groups. QT interval significantly decreased following drug administration in group 4 compared to groups 1 (P = 0.03) and 3 (P = 0.004). There were significant increases in the QT interval in groups 1 (P = 0.001) and 3 (P = 0.01) after drug injections. Heart rate (HR) significantly decreased in groups 1, 2 and 3 after drug injections (P = 0.004, 0.01 and 0.03, respectively). There was a significant negative correlation between HR, PR and QT intervals, and a positive correlation between HR and P-wave amplitude. There were no significant differences between all groups in the incidence of first and second degree AV blocks. UR - https://ijvr.shirazu.ac.ir/article_1694.html L1 - https://ijvr.shirazu.ac.ir/article_1694_606021453f4a88a46765f4a534eafa1f.pdf ER -